| http://purl.uniprot.org/citations/20860462 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20860462 | http://www.w3.org/2000/01/rdf-schema#comment | "AimImpaired heart rate (HR) response to exercise is associated with increased cardiovascular morbidity and mortality. We analyzed whether common variants (rs5443/C825T and rs5442/G814A) in the G-protein β3 subunit (GNB3) gene modulate interindividual variation in β-blocker responses with respect to HR.Materials & methodsAmong 1614 subjects (347 current β-blocker users) of a population-based study, HR during symptom-limited exercise testing was analyzed by multilevel linear regression models adjusted for potential confounders.ResultsIn β-blocker users, but not in nonusers, HR was attenuated in rs5443 T allele carriers (TC/TT vs CC) with lower adjusted HR over the entire exercise period from rest to peak workload (3.5 bpm; 95% CI: 1.1-5.8; p < 0.01), and during recovery (4.2 bpm; 95% CI: 0.6-7.8; p = 0.02). The genotype-related HR reducing effect at peak exercise varied by up to 7.5 bpm (CC vs TT), more than a third (35.9%) of the total β-blocker effect (20.9 bpm). By contrast, rs5442 had no impact on any HR-related parameter.ConclusionIn this population-based sample, a common GNB3 polymorphism (C825T) was significantly related with response to β-blocker therapy with respect to HR during exercise and HR recovery, respectively. Further prospective studies are needed to confirm these associations and to examine their potential clinical relevance."xsd:string |
| http://purl.uniprot.org/citations/20860462 | http://purl.org/dc/terms/identifier | "doi:10.2217/pgs.10.88"xsd:string |
| http://purl.uniprot.org/citations/20860462 | http://purl.uniprot.org/core/author | "Rosskopf D."xsd:string |
| http://purl.uniprot.org/citations/20860462 | http://purl.uniprot.org/core/author | "Schmidt C.O."xsd:string |
| http://purl.uniprot.org/citations/20860462 | http://purl.uniprot.org/core/author | "Kocher T."xsd:string |
| http://purl.uniprot.org/citations/20860462 | http://purl.uniprot.org/core/author | "Kroemer H.K."xsd:string |
| http://purl.uniprot.org/citations/20860462 | http://purl.uniprot.org/core/author | "Volzke H."xsd:string |
| http://purl.uniprot.org/citations/20860462 | http://purl.uniprot.org/core/author | "Franz C."xsd:string |
| http://purl.uniprot.org/citations/20860462 | http://purl.uniprot.org/core/author | "Diehl S.R."xsd:string |
| http://purl.uniprot.org/citations/20860462 | http://purl.uniprot.org/core/author | "Felix S.B."xsd:string |
| http://purl.uniprot.org/citations/20860462 | http://purl.uniprot.org/core/author | "Bornhorst A."xsd:string |
| http://purl.uniprot.org/citations/20860462 | http://purl.uniprot.org/core/author | "Dorr M."xsd:string |
| http://purl.uniprot.org/citations/20860462 | http://purl.uniprot.org/core/author | "Empen K."xsd:string |
| http://purl.uniprot.org/citations/20860462 | http://purl.uniprot.org/core/author | "Ewert R."xsd:string |
| http://purl.uniprot.org/citations/20860462 | http://purl.uniprot.org/core/author | "Hentschel K."xsd:string |
| http://purl.uniprot.org/citations/20860462 | http://purl.uniprot.org/core/author | "Spielhagen T."xsd:string |
| http://purl.uniprot.org/citations/20860462 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20860462 | http://purl.uniprot.org/core/name | "Pharmacogenomics"xsd:string |
| http://purl.uniprot.org/citations/20860462 | http://purl.uniprot.org/core/pages | "1209-1221"xsd:string |
| http://purl.uniprot.org/citations/20860462 | http://purl.uniprot.org/core/title | "beta-blocker therapy and heart rate control during exercise testing in the general population: role of a common G-protein beta-3 subunit variant."xsd:string |
| http://purl.uniprot.org/citations/20860462 | http://purl.uniprot.org/core/volume | "11"xsd:string |
| http://purl.uniprot.org/citations/20860462 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20860462 |
| http://purl.uniprot.org/citations/20860462 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20860462 |
| http://purl.uniprot.org/uniprot/#_E9PCP0-mappedCitation-20860462 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20860462 |