| http://purl.uniprot.org/citations/20861350 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20861350 | http://www.w3.org/2000/01/rdf-schema#comment | "Lysophosphatidic acid (LPA) is a phospholipid mediator that exerts a variety of biological responses through specific G-protein-coupled receptors (LPA(1)-LPA(5) and P2Y5). LPA is thought to be involved in airway inflammation by regulating the expression of anti-inflammatory and proinflammatory genes. Chemokines such as CCL5/RANTES are secreted from airway epithelium and play a key role in allergic airway inflammation. CCL5/RANTES is a chemoattractant for eosinophils, T lymphocytes, and monocytes and seems to exacerbate asthma. We stimulated CCL5/RANTES production in a human bronchial epithelial cell line, BEAS-2B, with IFN-γ and TNF-α. When LPA was added, CCL5/RANTES mRNA expression and protein secretion were inhibited, despite the presence of IFN-γ and TNF-α. The LPA effect was attenuated by Ki16425, a LPA(1)/LPA(3) antagonist, but not by dioctylglycerol pyrophosphate 8:0, an LPA(3) antagonist. Pertussis toxin, the inhibitors for PI3K and Akt also attenuated the inhibitory effect of LPA on CCL5/RANTES secretion. We also identify the transcription factor IFN regulatory factor-1 (IRF-1) as being essential for CCL5/RANTES production. Interestingly, LPA inhibited IFN-γ and TNF-α-induced IRF-1 activation by blocking the binding of IRF-1 to its DNA consensus sequence without changing IRF-1 induction and its nuclear translocation. Ki16425, pertussis toxin, and PI3K inhibitors attenuated the inhibitory effect of LPA on IRF-1 activation. Our results suggest that LPA inhibits IFN-γ- and TNF-α-induced CCL5/RANTES production in BEAS-2B cells by blocking the binding of IRF-1 to the CCL5/RANTES promoter. LPA(1) coupled to G(i) and activation of PI3K is required for this unique effect."xsd:string |
| http://purl.uniprot.org/citations/20861350 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.1000904"xsd:string |
| http://purl.uniprot.org/citations/20861350 | http://purl.uniprot.org/core/author | "Aoki H."xsd:string |
| http://purl.uniprot.org/citations/20861350 | http://purl.uniprot.org/core/author | "Matsuzaki S."xsd:string |
| http://purl.uniprot.org/citations/20861350 | http://purl.uniprot.org/core/author | "Mori M."xsd:string |
| http://purl.uniprot.org/citations/20861350 | http://purl.uniprot.org/core/author | "Ono A."xsd:string |
| http://purl.uniprot.org/citations/20861350 | http://purl.uniprot.org/core/author | "Koga Y."xsd:string |
| http://purl.uniprot.org/citations/20861350 | http://purl.uniprot.org/core/author | "Ishizuka T."xsd:string |
| http://purl.uniprot.org/citations/20861350 | http://purl.uniprot.org/core/author | "Tomura H."xsd:string |
| http://purl.uniprot.org/citations/20861350 | http://purl.uniprot.org/core/author | "Kurose H."xsd:string |
| http://purl.uniprot.org/citations/20861350 | http://purl.uniprot.org/core/author | "Hisada T."xsd:string |
| http://purl.uniprot.org/citations/20861350 | http://purl.uniprot.org/core/author | "Komachi M."xsd:string |
| http://purl.uniprot.org/citations/20861350 | http://purl.uniprot.org/core/author | "Okajima F."xsd:string |
| http://purl.uniprot.org/citations/20861350 | http://purl.uniprot.org/core/author | "Dobashi K."xsd:string |
| http://purl.uniprot.org/citations/20861350 | http://purl.uniprot.org/core/author | "Ichimonji I."xsd:string |
| http://purl.uniprot.org/citations/20861350 | http://purl.uniprot.org/core/author | "Utsugi M."xsd:string |
| http://purl.uniprot.org/citations/20861350 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20861350 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/20861350 | http://purl.uniprot.org/core/pages | "4863-4872"xsd:string |
| http://purl.uniprot.org/citations/20861350 | http://purl.uniprot.org/core/title | "Lysophosphatidic acid inhibits CC chemokine ligand 5/RANTES production by blocking IRF-1-mediated gene transcription in human bronchial epithelial cells."xsd:string |
| http://purl.uniprot.org/citations/20861350 | http://purl.uniprot.org/core/volume | "185"xsd:string |
| http://purl.uniprot.org/citations/20861350 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20861350 |
| http://purl.uniprot.org/citations/20861350 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20861350 |
| http://purl.uniprot.org/uniprot/#_D0EI67-mappedCitation-20861350 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20861350 |