| http://purl.uniprot.org/citations/20863706 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20863706 | http://www.w3.org/2000/01/rdf-schema#comment | "The aim of this study was to investigate the expression of microtubule-associated protein 1 light chain 3B (LC3B) and the autophagy-related gene Beclin 1 in astrocytic tumors and to analyze their expression profiles with respect to the development of astrocytic tumors. The expression patterns of LC3B and Beclin 1 were analyzed by immunohistochemistry and/or western blotting in tumor samples from 62 patients with different grades of astrocytic tumor. The expression patterns of LC3B and Beclin 1 were correlated with the pathological and clinical characteristics of the patients. Western blot analysis indicated that the average optical densitometry (OD) ratio of Beclin 1 in high-grade astrocytic tumors (World Health Organization [WHO] grade III/IV) was lower than in low-grade astrocytic tumors (WHO grade I/II, p = 0.036). The expression of LC3B-I exhibited no significant difference among the various grades of astrocytic tumor. However, the average OD ratio of LC3B-II was lower in glioblastoma multiforme (GBM) than in other grades of astrocytic tumor (p = 0.030). The expression levels of Beclin 1 and LC3B-II were related to survival time and they were also correlated with each other (p = 0.035). In addition, down-regulation of LC3B-II and Beclin 1 expression was associated with GBM. The progression of astrocytic tumors was related to a decrease in autophagic capacity represented by the loss of LC3B-II and Beclin 1 expression."xsd:string |
| http://purl.uniprot.org/citations/20863706 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.jocn.2010.03.051"xsd:string |
| http://purl.uniprot.org/citations/20863706 | http://purl.uniprot.org/core/author | "Chen L."xsd:string |
| http://purl.uniprot.org/citations/20863706 | http://purl.uniprot.org/core/author | "Huang X."xsd:string |
| http://purl.uniprot.org/citations/20863706 | http://purl.uniprot.org/core/author | "Li B."xsd:string |
| http://purl.uniprot.org/citations/20863706 | http://purl.uniprot.org/core/author | "Lu Y.C."xsd:string |
| http://purl.uniprot.org/citations/20863706 | http://purl.uniprot.org/core/author | "Bai H.M."xsd:string |
| http://purl.uniprot.org/citations/20863706 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20863706 | http://purl.uniprot.org/core/name | "J Clin Neurosci"xsd:string |
| http://purl.uniprot.org/citations/20863706 | http://purl.uniprot.org/core/pages | "1515-1519"xsd:string |
| http://purl.uniprot.org/citations/20863706 | http://purl.uniprot.org/core/title | "Reduced expression of LC3B-II and Beclin 1 in glioblastoma multiforme indicates a down-regulated autophagic capacity that relates to the progression of astrocytic tumors."xsd:string |
| http://purl.uniprot.org/citations/20863706 | http://purl.uniprot.org/core/volume | "17"xsd:string |
| http://purl.uniprot.org/citations/20863706 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20863706 |
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