| http://purl.uniprot.org/citations/20863901 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20863901 | http://www.w3.org/2000/01/rdf-schema#comment | "Cyclin E, a member of the G1 cyclins, is essential for the G1/S transition of the cell cycle in cultured cells, but its roles in vivo are not fully defined. The present study characterized the spatiotemporal expression profile of cyclin E in two representative brain regions in the mouse, the cerebral and cerebellar cortices. Western blotting showed that the levels of cyclin E increased towards adulthood. In situ hybridization and immunohistochemistry showed the distributions of cyclin E mRNA and protein were comparable in the cerebral cortex and the cerebellum. Immunohistochemistry for the proliferating cell marker, proliferating cell nuclear antigen (PCNA) revealed that cyclin E was expressed by both proliferating and non-proliferating cells in the cerebral cortex at embryonic day 12.5 (E12.5) and in the cerebellum at postnatal day 1 (P1). Subcellular localization in neurons was examined using immunofluorescence and western blotting. Cyclin E expression was nuclear in proliferating neuronal precursor cells but cytoplasmic in postmitotic neurons during embryonic development. Nuclear cyclin E expression in neurons remained faint in newborns, increased during postnatal development and was markedly decreased in adults. In various adult brain regions, cyclin E staining was more intense in the cytoplasm than in the nucleus in most neurons. These data suggest a role for cyclin E in the development and function of the mammalian central nervous system and that its subcellular localization in neurons is important. Our report presents the first detailed analysis of cyclin E expression in postmitotic neurons during development and in the adult mouse brain."xsd:string |
| http://purl.uniprot.org/citations/20863901 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.gep.2010.09.004"xsd:string |
| http://purl.uniprot.org/citations/20863901 | http://purl.uniprot.org/core/author | "Ikeda Y."xsd:string |
| http://purl.uniprot.org/citations/20863901 | http://purl.uniprot.org/core/author | "Takiguchi M."xsd:string |
| http://purl.uniprot.org/citations/20863901 | http://purl.uniprot.org/core/author | "Matsunaga Y."xsd:string |
| http://purl.uniprot.org/citations/20863901 | http://purl.uniprot.org/core/author | "Ikeda M.A."xsd:string |
| http://purl.uniprot.org/citations/20863901 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/20863901 | http://purl.uniprot.org/core/name | "Gene Expr Patterns"xsd:string |
| http://purl.uniprot.org/citations/20863901 | http://purl.uniprot.org/core/pages | "64-71"xsd:string |
| http://purl.uniprot.org/citations/20863901 | http://purl.uniprot.org/core/title | "Expression of cyclin E in postmitotic neurons during development and in the adult mouse brain."xsd:string |
| http://purl.uniprot.org/citations/20863901 | http://purl.uniprot.org/core/volume | "11"xsd:string |
| http://purl.uniprot.org/citations/20863901 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20863901 |
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