| http://purl.uniprot.org/citations/20869045 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20869045 | http://www.w3.org/2000/01/rdf-schema#comment | "Fc receptor-like A (FCRLA) and FCRLB have homology to the transmembrane FCRL family members (FCRL 1-6) and to the conventional receptors for the Fc portion of immunoglobulin, but uniquely are cytosolic proteins expressed in B cells. Here we describe the phenotype of Fcrlb-gene targeted mice. B cell development and in vitro responses are normal; however, antibody responses to a T-dependent antigen are elevated. The gene encoding the inhibitory FcγRIIb is located nearby Fcrlb. Although Fcrlb-gene targeting had no effect on the function or basal expression of FcγRIIb, its expression was reduced following activation. This abnormal regulation was due to co-inheritance of Fcgr2b and the mutant Fcrlb allele from the 129 ES cells. A promoter polymorphism in the 129/Sv Fcgr2b allele results in diminished upregulation of FcγRIIb following B cell activation. Thus, we speculate that the enhanced antibody response seen in the FCRLB-deficient mice may be due to the Fcgr2b promoter."xsd:string |
| http://purl.uniprot.org/citations/20869045 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cellimm.2010.08.007"xsd:string |
| http://purl.uniprot.org/citations/20869045 | http://purl.uniprot.org/core/author | "Mori H."xsd:string |
| http://purl.uniprot.org/citations/20869045 | http://purl.uniprot.org/core/author | "Nakayama M."xsd:string |
| http://purl.uniprot.org/citations/20869045 | http://purl.uniprot.org/core/author | "Ohara O."xsd:string |
| http://purl.uniprot.org/citations/20869045 | http://purl.uniprot.org/core/author | "Wang J.Y."xsd:string |
| http://purl.uniprot.org/citations/20869045 | http://purl.uniprot.org/core/author | "Masuda K."xsd:string |
| http://purl.uniprot.org/citations/20869045 | http://purl.uniprot.org/core/author | "Burrows P.D."xsd:string |
| http://purl.uniprot.org/citations/20869045 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20869045 | http://purl.uniprot.org/core/name | "Cell Immunol"xsd:string |
| http://purl.uniprot.org/citations/20869045 | http://purl.uniprot.org/core/pages | "24-31"xsd:string |
| http://purl.uniprot.org/citations/20869045 | http://purl.uniprot.org/core/title | "Defining the immunological phenotype of Fc receptor-like B (FCRLB) deficient mice: Confounding role of the inhibitory FcgammaRIIb."xsd:string |
| http://purl.uniprot.org/citations/20869045 | http://purl.uniprot.org/core/volume | "266"xsd:string |
| http://purl.uniprot.org/citations/20869045 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20869045 |
| http://purl.uniprot.org/citations/20869045 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20869045 |
| http://purl.uniprot.org/uniprot/Q5DRQ8#attribution-B305BBD2A6441EBCEEFDDAF40C6C124D | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/20869045 |
| http://purl.uniprot.org/uniprot/#_A0A0B4J1E6-mappedCitation-20869045 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20869045 |
| http://purl.uniprot.org/uniprot/#_A0A0B4J1G1-mappedCitation-20869045 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20869045 |
| http://purl.uniprot.org/uniprot/#_E9Q415-mappedCitation-20869045 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20869045 |
| http://purl.uniprot.org/uniprot/#_P08101-mappedCitation-20869045 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20869045 |
| http://purl.uniprot.org/uniprot/#_P97918-mappedCitation-20869045 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20869045 |
| http://purl.uniprot.org/uniprot/#_Q5DRQ8-mappedCitation-20869045 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20869045 |
| http://purl.uniprot.org/uniprot/Q5DRQ8 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/20869045 |
| http://purl.uniprot.org/uniprot/A0A0B4J1G1 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/20869045 |