| http://purl.uniprot.org/citations/20870940 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20870940 | http://www.w3.org/2000/01/rdf-schema#comment | "Gene-targeted mice deficient in the complement mannose-binding lectin-associated serine protease-1 and -3 (MASP1/3(-/-)) express only the zymogen of factor D (pro-factor D [pro-Df]), a necessary component of the alternative pathway (AP). We used the murine collagen Ab-induced arthritis (CAIA) model, in which the AP is unique among complement pathways in being both necessary and sufficient for disease induction, to determine whether MASP-1/3 are required in vivo for the development of tissue injury. Disease activity scores, complement C3 tissue deposition in the joint, and histopathologic injury scores were markedly decreased in MASP1/3(-/-) as compared with wild-type (WT) mice. MASP-1 protein was immunochemically localized to synovial cells of knees of WT mice with arthritis. Pro-Df was present in both synovial cells and chondrocytes of knees of WT and MASP1/3(-/-) mice without arthritis, with increased amounts present in synovial cells of WT mice with CAIA. No conversion of pro-Df to mature Df was detectable in the serum of MASP1/3(-/-) mice during the evolution of CAIA. C3 activation and deposition as well as C5a generation induced in vitro by adherent anti-type II collagen mAbs were absent using sera from MASP1/3(-/-) mice under conditions in which only the AP was active. The addition of human Df fully reconstituted in vitro C3 activation and C5a generation using sera from MASP1/3(-/-) mice. Our studies demonstrate for the first time, to our knowledge, the absolute requirement for the activity of MASP-1 protein in autoimmune-associated inflammatory tissue injury in vivo through activation of the AP of complement by cleavage of pro-Df to mature Df."xsd:string |
| http://purl.uniprot.org/citations/20870940 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.1001564"xsd:string |
| http://purl.uniprot.org/citations/20870940 | http://purl.uniprot.org/core/author | "Nicholas J."xsd:string |
| http://purl.uniprot.org/citations/20870940 | http://purl.uniprot.org/core/author | "Fujita T."xsd:string |
| http://purl.uniprot.org/citations/20870940 | http://purl.uniprot.org/core/author | "Takahashi K."xsd:string |
| http://purl.uniprot.org/citations/20870940 | http://purl.uniprot.org/core/author | "Takahashi M."xsd:string |
| http://purl.uniprot.org/citations/20870940 | http://purl.uniprot.org/core/author | "Holers V.M."xsd:string |
| http://purl.uniprot.org/citations/20870940 | http://purl.uniprot.org/core/author | "Stahl G.L."xsd:string |
| http://purl.uniprot.org/citations/20870940 | http://purl.uniprot.org/core/author | "Arend W.P."xsd:string |
| http://purl.uniprot.org/citations/20870940 | http://purl.uniprot.org/core/author | "Banda N.K."xsd:string |
| http://purl.uniprot.org/citations/20870940 | http://purl.uniprot.org/core/author | "Levitt B."xsd:string |
| http://purl.uniprot.org/citations/20870940 | http://purl.uniprot.org/core/author | "Glogowska M."xsd:string |
| http://purl.uniprot.org/citations/20870940 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20870940 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/20870940 | http://purl.uniprot.org/core/pages | "5598-5606"xsd:string |
| http://purl.uniprot.org/citations/20870940 | http://purl.uniprot.org/core/title | "Essential role of complement mannose-binding lectin-associated serine proteases-1/3 in the murine collagen antibody-induced model of inflammatory arthritis."xsd:string |
| http://purl.uniprot.org/citations/20870940 | http://purl.uniprot.org/core/volume | "185"xsd:string |
| http://purl.uniprot.org/citations/20870940 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20870940 |
| http://purl.uniprot.org/citations/20870940 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20870940 |
| http://purl.uniprot.org/uniprot/#_A0A2R8VHR3-mappedCitation-20870940 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20870940 |
| http://purl.uniprot.org/uniprot/#_A0A3B0IP04-mappedCitation-20870940 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20870940 |
| http://purl.uniprot.org/uniprot/#_E1APH6-mappedCitation-20870940 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20870940 |
| http://purl.uniprot.org/uniprot/#_B5APU1-mappedCitation-20870940 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20870940 |
| http://purl.uniprot.org/uniprot/#_F6XQ00-mappedCitation-20870940 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20870940 |