| http://purl.uniprot.org/citations/20870947 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20870947 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20870947 | http://www.w3.org/2000/01/rdf-schema#comment | "The mitotic checkpoint is essential for maintaining genomic stability in differentiating B cells undergoing genetic alterations of the Ig gene. In this study, using real-time RT-PCR and in situ RNA hybridization, we demonstrated that MAD2 mRNA export is selectively regulated by Pcid2/Thp1. Pcid2 small interfering RNA induced a cell-cycle abnormality with increased apoptosis and polyploidy, as previously observed in MAD2-knockdown cells. Pcid2 small interfering RNA reduced MAD2 expression, but not the expression of other cell-cycle checkpoint proteins, such as MAD1 and BUBR1, or the cell-cycle-associated proteins, cyclin A, cyclin B1, and cyclin-dependent kinase 1. In mouse B lineage cells, Pcid2 transcripts appeared in a stage-dependent manner at high levels in bone marrow pre-B and immature B cells, and in spleen transitional 1 and follicular B cells, but at lower levels in pro-B, transitional 2, and marginal zone B cells, suggesting a stage-dependent requirement for MAD2 regulation. Cd19-cre-derived targeting of the Pcid2 gene induced a mature B cell deficiency in mice. These findings indicate that Pcid2 is essential for B cell survival through the regulation of MAD2 expression during B cell differentiation."xsd:string |
| http://purl.uniprot.org/citations/20870947 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.1002026"xsd:string |
| http://purl.uniprot.org/citations/20870947 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.1002026"xsd:string |
| http://purl.uniprot.org/citations/20870947 | http://purl.uniprot.org/core/author | "Nakaya T."xsd:string |
| http://purl.uniprot.org/citations/20870947 | http://purl.uniprot.org/core/author | "Nakaya T."xsd:string |
| http://purl.uniprot.org/citations/20870947 | http://purl.uniprot.org/core/author | "Tani T."xsd:string |
| http://purl.uniprot.org/citations/20870947 | http://purl.uniprot.org/core/author | "Tani T."xsd:string |
| http://purl.uniprot.org/citations/20870947 | http://purl.uniprot.org/core/author | "Ohta K."xsd:string |
| http://purl.uniprot.org/citations/20870947 | http://purl.uniprot.org/core/author | "Ohta K."xsd:string |
| http://purl.uniprot.org/citations/20870947 | http://purl.uniprot.org/core/author | "Takeda N."xsd:string |
| http://purl.uniprot.org/citations/20870947 | http://purl.uniprot.org/core/author | "Takeda N."xsd:string |
| http://purl.uniprot.org/citations/20870947 | http://purl.uniprot.org/core/author | "Sakaguchi N."xsd:string |
| http://purl.uniprot.org/citations/20870947 | http://purl.uniprot.org/core/author | "Sakaguchi N."xsd:string |
| http://purl.uniprot.org/citations/20870947 | http://purl.uniprot.org/core/author | "Kitabatake M."xsd:string |
| http://purl.uniprot.org/citations/20870947 | http://purl.uniprot.org/core/author | "Kitabatake M."xsd:string |
| http://purl.uniprot.org/citations/20870947 | http://purl.uniprot.org/core/author | "Kuwahara K."xsd:string |
| http://purl.uniprot.org/citations/20870947 | http://purl.uniprot.org/core/author | "Kuwahara K."xsd:string |
| http://purl.uniprot.org/citations/20870947 | http://purl.uniprot.org/core/author | "Toda T."xsd:string |
| http://purl.uniprot.org/citations/20870947 | http://purl.uniprot.org/core/author | "Toda T."xsd:string |
| http://purl.uniprot.org/citations/20870947 | http://purl.uniprot.org/core/author | "Kondo E."xsd:string |
| http://purl.uniprot.org/citations/20870947 | http://purl.uniprot.org/core/author | "Kondo E."xsd:string |
| http://purl.uniprot.org/citations/20870947 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20870947 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |