| http://purl.uniprot.org/citations/20876237 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20876237 | http://www.w3.org/2000/01/rdf-schema#comment | "Although vgf gene knockout mice are hypermetabolic, administration of the VGF peptide TLQP-21 itself increased energy consumption. Agonist-antagonist roles are thus suggested for different VGF peptides, and the definition of their tissue heterogeneity is mandatory. We studied the rat stomach using antisera to C- or N-terminal sequences of known or predicted VGF peptides in immunohistochemistry and ELISA. TLQP (rat VGF(556-565)) peptide/s were most abundant (162±11 pmol/g, mean±s.e.m.) and were brightly immunostained in enterochromaffin-like (ECL) cells and somatostatin cells. A peptide co-eluting with TLQP-21 was revealed in HPLC of gastric and hypothalamic extracts, while the extended TLQP-62 form was restricted to the hypothalamus. Novel PGH (rat VGF(422-430)) peptide/s were revealed in ghrelin cells, mostly corresponding to low MW forms (0.8-1.5 kDa), while VGF C-terminus peptides were confined to neurons. VGF mRNA was present in the above gastric endocrine cell types, and was prominent in chief cells, in parallel with low-intensity staining for further cleaved products from the C-terminal region of VGF (HVLL peptides: VGF(605-614)). In swine stomach, a comparable profile of VGF peptides was revealed by immunohistochemistry. When fed and fasted rats were studied, a clear-cut, selective decrease on fasting was observed for TLQP peptides only (162±11 vs 74±5.3 pmol/g, fed versus fasted rats, mean±s.e.m., P<0.00001). In conclusion, specific VGF peptides appear to be widely represented in different gastric endocrine and other mucosal cell populations. The selective modulation of TLQP peptides suggests their involvement in peripheral neuro-endocrine mechanisms related to feeding responses and/or ECL cell regulation."xsd:string |
| http://purl.uniprot.org/citations/20876237 | http://purl.org/dc/terms/identifier | "doi:10.1677/joe-10-0189"xsd:string |
| http://purl.uniprot.org/citations/20876237 | http://purl.uniprot.org/core/author | "Possenti R."xsd:string |
| http://purl.uniprot.org/citations/20876237 | http://purl.uniprot.org/core/author | "Argiolas A."xsd:string |
| http://purl.uniprot.org/citations/20876237 | http://purl.uniprot.org/core/author | "Brancia C."xsd:string |
| http://purl.uniprot.org/citations/20876237 | http://purl.uniprot.org/core/author | "Ferri G.L."xsd:string |
| http://purl.uniprot.org/citations/20876237 | http://purl.uniprot.org/core/author | "D'Amato F."xsd:string |
| http://purl.uniprot.org/citations/20876237 | http://purl.uniprot.org/core/author | "Sanna F."xsd:string |
| http://purl.uniprot.org/citations/20876237 | http://purl.uniprot.org/core/author | "Cocco C."xsd:string |
| http://purl.uniprot.org/citations/20876237 | http://purl.uniprot.org/core/author | "Noli B."xsd:string |
| http://purl.uniprot.org/citations/20876237 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20876237 | http://purl.uniprot.org/core/name | "J Endocrinol"xsd:string |
| http://purl.uniprot.org/citations/20876237 | http://purl.uniprot.org/core/pages | "329-341"xsd:string |
| http://purl.uniprot.org/citations/20876237 | http://purl.uniprot.org/core/title | "Selective expression of TLQP-21 and other VGF peptides in gastric neuroendocrine cells and modulation by feeding."xsd:string |
| http://purl.uniprot.org/citations/20876237 | http://purl.uniprot.org/core/volume | "207"xsd:string |
| http://purl.uniprot.org/citations/20876237 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20876237 |
| http://purl.uniprot.org/citations/20876237 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20876237 |
| http://purl.uniprot.org/uniprot/#_A6J052-mappedCitation-20876237 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20876237 |
| http://purl.uniprot.org/uniprot/#_P20156-mappedCitation-20876237 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20876237 |
| http://purl.uniprot.org/uniprot/A6J052 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/20876237 |
| http://purl.uniprot.org/uniprot/P20156 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/20876237 |