| http://purl.uniprot.org/citations/20876804 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20876804 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20876804 | http://www.w3.org/2000/01/rdf-schema#comment | "Aberrant expression and polymorphism of fibroblast growth factor receptor 4 (FGFR4) has been linked to tumor progression and anticancer drug resistance. We describe here a novel mechanism of tumor progression by matrix degradation involving epithelial-to-mesenchymal transition in response to membrane-type 1 matrix metalloproteinase (MT1-MMP, MMP-14) induction at the edge of tumors expressing the FGFR4-R388 risk variant. Both FGFR4 and MT1-MMP were upregulated in tissue biopsies from several human cancer types including breast adenocarcinomas, where they were partially coexpressed at the tumor/stroma border and tumor invasion front. The strongest overall coexpression was found in prostate carcinoma. Studies with cultured prostate carcinoma cell lines showed that the FGFR4-R388 variant, which has previously been associated with poor cancer prognosis, increased MT1-MMP-dependent collagen invasion. In this experimental model, knockdown of FGFR4-R388 or MT1-MMP by RNA interference blocked tumor cell invasion and growth in collagen. This was coupled with impaired phosphorylation of FGFR substrate 2 and Src, upregulation of E-cadherin, and suppression of cadherin-11 and N-cadherin. These in vitro results were substantiated by reduced MT1-MMP content and in vivo growth of prostate carcinoma cells after the FGFR4-R388 gene silencing. In contrast, knockdown of the alternative FGFR4-G388 allele enhanced MT1-MMP and invasive tumor cell growth in vivo and within three-dimensional collagen. These results will help to explain the reported association of the FGFR4-R388 variant with the progression and poor prognosis of certain types of tumors."xsd:string |
| http://purl.uniprot.org/citations/20876804 | http://purl.org/dc/terms/identifier | "doi:10.1158/0008-5472.can-10-1223"xsd:string |
| http://purl.uniprot.org/citations/20876804 | http://purl.org/dc/terms/identifier | "doi:10.1158/0008-5472.can-10-1223"xsd:string |
| http://purl.uniprot.org/citations/20876804 | http://purl.uniprot.org/core/author | "Sugiyama N."xsd:string |
| http://purl.uniprot.org/citations/20876804 | http://purl.uniprot.org/core/author | "Sugiyama N."xsd:string |
| http://purl.uniprot.org/citations/20876804 | http://purl.uniprot.org/core/author | "Alitalo K."xsd:string |
| http://purl.uniprot.org/citations/20876804 | http://purl.uniprot.org/core/author | "Alitalo K."xsd:string |
| http://purl.uniprot.org/citations/20876804 | http://purl.uniprot.org/core/author | "Taipale J."xsd:string |
| http://purl.uniprot.org/citations/20876804 | http://purl.uniprot.org/core/author | "Taipale J."xsd:string |
| http://purl.uniprot.org/citations/20876804 | http://purl.uniprot.org/core/author | "Varjosalo M."xsd:string |
| http://purl.uniprot.org/citations/20876804 | http://purl.uniprot.org/core/author | "Varjosalo M."xsd:string |
| http://purl.uniprot.org/citations/20876804 | http://purl.uniprot.org/core/author | "Kallioniemi O."xsd:string |
| http://purl.uniprot.org/citations/20876804 | http://purl.uniprot.org/core/author | "Kallioniemi O."xsd:string |
| http://purl.uniprot.org/citations/20876804 | http://purl.uniprot.org/core/author | "Kilpinen S."xsd:string |
| http://purl.uniprot.org/citations/20876804 | http://purl.uniprot.org/core/author | "Kilpinen S."xsd:string |
| http://purl.uniprot.org/citations/20876804 | http://purl.uniprot.org/core/author | "Engelholm L.H."xsd:string |
| http://purl.uniprot.org/citations/20876804 | http://purl.uniprot.org/core/author | "Engelholm L.H."xsd:string |
| http://purl.uniprot.org/citations/20876804 | http://purl.uniprot.org/core/author | "Lohi J."xsd:string |
| http://purl.uniprot.org/citations/20876804 | http://purl.uniprot.org/core/author | "Lohi J."xsd:string |
| http://purl.uniprot.org/citations/20876804 | http://purl.uniprot.org/core/author | "Hyytiainen M."xsd:string |
| http://purl.uniprot.org/citations/20876804 | http://purl.uniprot.org/core/author | "Hyytiainen M."xsd:string |
| http://purl.uniprot.org/citations/20876804 | http://purl.uniprot.org/core/author | "Ingvarsen S."xsd:string |
| http://purl.uniprot.org/citations/20876804 | http://purl.uniprot.org/core/author | "Ingvarsen S."xsd:string |