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| http://purl.uniprot.org/citations/20876993 | http://www.w3.org/2000/01/rdf-schema#comment | "DOA kinase, the Drosophila member of the LAMMER/Clk protein kinase family, phosphorylates SR and SR-like proteins, including TRA, TRA2 and RBP1, which are responsible for the alternative splicing of transcripts encoding the key regulator of sex-specific expression in somatic cells of the fly, DOUBLESEX. Specific Doa alleles induce somatic female-to-male sex transformations, which can be enhanced when combined with mutations in loci encoding SR and SR-like proteins. The Doa locus encodes six different kinases, of which a 69-kDa isoform is expressed solely in females. Expression of this isoform is itself under the regulation of the somatic sex determination regulatory network, thus forming a putative positive autoregulatory loop which would reinforce the choice of the female cell-fate. We speculate that this loop is part of the evolutionary ancestral sex-determination machinery, based upon evidence demonstrating the existence of an autoregulatory loop involving TRA and TRA2 in several other insect species."xsd:string |
| http://purl.uniprot.org/citations/20876993 | http://purl.org/dc/terms/identifier | "doi:10.1007/s12041-010-0038-6"xsd:string |
| http://purl.uniprot.org/citations/20876993 | http://purl.uniprot.org/core/author | "Rabinow L."xsd:string |
| http://purl.uniprot.org/citations/20876993 | http://purl.uniprot.org/core/author | "Samson M.L."xsd:string |
| http://purl.uniprot.org/citations/20876993 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20876993 | http://purl.uniprot.org/core/name | "J Genet"xsd:string |
| http://purl.uniprot.org/citations/20876993 | http://purl.uniprot.org/core/pages | "271-277"xsd:string |
| http://purl.uniprot.org/citations/20876993 | http://purl.uniprot.org/core/title | "The role of the Drosophila LAMMER protein kinase DOA in somatic sex determination."xsd:string |
| http://purl.uniprot.org/citations/20876993 | http://purl.uniprot.org/core/volume | "89"xsd:string |
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