| http://purl.uniprot.org/citations/20880607 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20880607 | http://www.w3.org/2000/01/rdf-schema#comment | "Alzheimer's disease (AD) has a complex pattern of inheritance and many genes have recently been reported to contribute to the disease susceptibility. We selected 106 SNPs within 16 candidate genes and performed a multistage association study using 4 sample sets consisting of 731 AD patients and 738 control subjects to identify genetic factors for AD in Han Chinese. A single nucleotide polymorphism (SNP) in the insulin degrading enzyme gene (IDE), rs3781239, showed a significant association with AD. The C allele increased the risk of AD 1.72-fold than the G allele (odds ratio [OR] = 1.72, 95% confidence interval [CI] = 1.17-2.53, p = 0.006) and CC carriers had a 4.89-fold higher risk for AD than that of the carriers with CG and GG genotypes (odds ratio = 4.89, 95% CI = 1.85-12.91, p = 0.001). Moreover, the CC genotype was significantly associated with earlier age at onset (p = 0.001, hazard ratio [HR] = 2.09, 95% CI = 1.38-3.18). Our data suggest that the polymorphism of IDE is associated with susceptibility to Alzheimer's disease in Han Chinese."xsd:string |
| http://purl.uniprot.org/citations/20880607 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.neurobiolaging.2010.08.004"xsd:string |
| http://purl.uniprot.org/citations/20880607 | http://purl.uniprot.org/core/author | "Jia J."xsd:string |
| http://purl.uniprot.org/citations/20880607 | http://purl.uniprot.org/core/author | "Zhang Y."xsd:string |
| http://purl.uniprot.org/citations/20880607 | http://purl.uniprot.org/core/author | "Zhang F."xsd:string |
| http://purl.uniprot.org/citations/20880607 | http://purl.uniprot.org/core/author | "Song H."xsd:string |
| http://purl.uniprot.org/citations/20880607 | http://purl.uniprot.org/core/author | "Wang F."xsd:string |
| http://purl.uniprot.org/citations/20880607 | http://purl.uniprot.org/core/author | "Wei C."xsd:string |
| http://purl.uniprot.org/citations/20880607 | http://purl.uniprot.org/core/author | "Tang M."xsd:string |
| http://purl.uniprot.org/citations/20880607 | http://purl.uniprot.org/core/author | "Zhou A."xsd:string |
| http://purl.uniprot.org/citations/20880607 | http://purl.uniprot.org/core/author | "Shu C."xsd:string |
| http://purl.uniprot.org/citations/20880607 | http://purl.uniprot.org/core/author | "Qin W."xsd:string |
| http://purl.uniprot.org/citations/20880607 | http://purl.uniprot.org/core/author | "Hong Z."xsd:string |
| http://purl.uniprot.org/citations/20880607 | http://purl.uniprot.org/core/author | "Jia L."xsd:string |
| http://purl.uniprot.org/citations/20880607 | http://purl.uniprot.org/core/author | "Zuo X."xsd:string |
| http://purl.uniprot.org/citations/20880607 | http://purl.uniprot.org/core/author | "Wang D.M."xsd:string |
| http://purl.uniprot.org/citations/20880607 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/20880607 | http://purl.uniprot.org/core/name | "Neurobiol Aging"xsd:string |
| http://purl.uniprot.org/citations/20880607 | http://purl.uniprot.org/core/pages | "1014.e1-9"xsd:string |
| http://purl.uniprot.org/citations/20880607 | http://purl.uniprot.org/core/title | "Exploration of 16 candidate genes identifies the association of IDE with Alzheimer's disease in Han Chinese."xsd:string |
| http://purl.uniprot.org/citations/20880607 | http://purl.uniprot.org/core/volume | "33"xsd:string |
| http://purl.uniprot.org/citations/20880607 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20880607 |
| http://purl.uniprot.org/citations/20880607 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20880607 |
| http://purl.uniprot.org/uniprot/#_A0A125SXW0-mappedCitation-20880607 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20880607 |