| http://purl.uniprot.org/citations/20881313 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20881313 | http://www.w3.org/2000/01/rdf-schema#comment | "Vitamin A (retinol) is required for maintenance of adult mammalian spermatogenesis. In adult rodents, vitamin A withdrawal is followed by a loss of differentiated germ cells within the seminiferous epithelium and disrupted spermatogenesis that can be restored by vitamin A replacement. However, whether vitamin A plays a role in the differentiation and meiotic initiation of germ cells during the first round of mouse spermatogenesis is unknown. In the present study, we found that vitamin A depletion markedly decreased testicular expression of the all-trans retinoic acid-responsive gene, Stra8, and caused meiotic failure in prepubertal male mice lacking lecithin:retinol acyltransferase (Lrat), encoding for the major enzyme in liver responsible for the formation of retinyl esters. Rather than undergoing normal differentiation, germ cells accumulated in the testes of Lrat(-/-) mice maintained on a vitamin A-deficient diet. These results, together with our previous observations that germ cells fail to enter meiosis and remain undifferentiated in embryonic vitamin A-deficient ovaries, support the hypothesis that vitamin A regulates the initiation of meiosis I of both oogenesis and spermatogenesis in mammals."xsd:string |
| http://purl.uniprot.org/citations/20881313 | http://purl.org/dc/terms/identifier | "doi:10.1095/biolreprod.110.086157"xsd:string |
| http://purl.uniprot.org/citations/20881313 | http://purl.uniprot.org/core/author | "Li H."xsd:string |
| http://purl.uniprot.org/citations/20881313 | http://purl.uniprot.org/core/author | "Baehr W."xsd:string |
| http://purl.uniprot.org/citations/20881313 | http://purl.uniprot.org/core/author | "Palczewski K."xsd:string |
| http://purl.uniprot.org/citations/20881313 | http://purl.uniprot.org/core/author | "Clagett-Dame M."xsd:string |
| http://purl.uniprot.org/citations/20881313 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/20881313 | http://purl.uniprot.org/core/name | "Biol Reprod"xsd:string |
| http://purl.uniprot.org/citations/20881313 | http://purl.uniprot.org/core/pages | "336-341"xsd:string |
| http://purl.uniprot.org/citations/20881313 | http://purl.uniprot.org/core/title | "Vitamin A deficiency results in meiotic failure and accumulation of undifferentiated spermatogonia in prepubertal mouse testis."xsd:string |
| http://purl.uniprot.org/citations/20881313 | http://purl.uniprot.org/core/volume | "84"xsd:string |
| http://purl.uniprot.org/citations/20881313 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20881313 |
| http://purl.uniprot.org/citations/20881313 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20881313 |
| http://purl.uniprot.org/uniprot/#_B2RUR5-mappedCitation-20881313 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20881313 |
| http://purl.uniprot.org/uniprot/#_Q9JI60-mappedCitation-20881313 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20881313 |
| http://purl.uniprot.org/uniprot/B2RUR5 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/20881313 |
| http://purl.uniprot.org/uniprot/Q9JI60 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/20881313 |