| http://purl.uniprot.org/citations/20889132 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20889132 | http://www.w3.org/2000/01/rdf-schema#comment | "Peroxisome proliferator-activated receptor (PPAR) γ coactivator-1β (PGC-1β) is a transcriptional coactivator that induces hypertriglyceridemia in response to dietary fats through activating hepatic lipogenesis and lipoprotein secretion. The expression of PGC-1β is regulated by free fatty acids. Here we show that PGC-1β regulates plasma triglyceride metabolism through stimulating apolipoprotein C3 (APOC3) expression and elevating APOC3 levels in circulation. Remarkably, liver-specific knockdown of APOC3 significantly ameliorates PGC-1β-induced hypertriglyceridemia in mice. Hepatic expression of PGC-1β and APOC3 is reduced in response to acute and chronic treatments with nicotinic acid, a widely prescribed drug for lowering plasma triglycerides. Adenoviral-mediated knockdown of PGC-1β or APOC3 in the liver recapitulates the hypolipidemic effect of nicotinic acid. Proteomic analysis of hepatic PGC-1β transcriptional complex indicates that it stimulates APOC3 expression through coactivating orphan nuclear receptor ERRα and recruiting chromatin-remodeling cofactors. Together, these studies identify PGC-1β as an important regulator of the APOC3 gene cluster and reveal a mechanism through which nicotinic acid achieves its therapeutic effects."xsd:string |
| http://purl.uniprot.org/citations/20889132 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cmet.2010.09.001"xsd:string |
| http://purl.uniprot.org/citations/20889132 | http://purl.uniprot.org/core/author | "Li S."xsd:string |
| http://purl.uniprot.org/citations/20889132 | http://purl.uniprot.org/core/author | "Li Y."xsd:string |
| http://purl.uniprot.org/citations/20889132 | http://purl.uniprot.org/core/author | "Hernandez C."xsd:string |
| http://purl.uniprot.org/citations/20889132 | http://purl.uniprot.org/core/author | "Lin J.D."xsd:string |
| http://purl.uniprot.org/citations/20889132 | http://purl.uniprot.org/core/author | "Molusky M."xsd:string |
| http://purl.uniprot.org/citations/20889132 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20889132 | http://purl.uniprot.org/core/name | "Cell Metab"xsd:string |
| http://purl.uniprot.org/citations/20889132 | http://purl.uniprot.org/core/pages | "411-419"xsd:string |
| http://purl.uniprot.org/citations/20889132 | http://purl.uniprot.org/core/title | "Regulation of hepatic ApoC3 expression by PGC-1beta mediates hypolipidemic effect of nicotinic acid."xsd:string |
| http://purl.uniprot.org/citations/20889132 | http://purl.uniprot.org/core/volume | "12"xsd:string |
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