DESCRIBE <http://purl.uniprot.org/citations/20889853>

Subject	Predicate	Object
http://purl.uniprot.org/citations/20889853	http://www.w3.org/1999/02/22-rdf-syntax-ns#type	http://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/20889853	http://www.w3.org/2000/01/rdf-schema#comment	" Objective To test if knowledge of type 2 diabetes genetic variants improves disease prediction. Research design and methods We tested 40 single nucleotide polymorphisms (SNPs) associated with diabetes in 3,471 Framingham Offspring Study subjects followed over 34 years using pooled logistic regression models stratified by age (<50 years, diabetes cases = 144; or ≥50 years, diabetes cases = 302). Models included clinical risk factors and a 40-SNP weighted genetic risk score. Results In people <50 years of age, the clinical risk factors model C-statistic was 0.908; the 40-SNP score increased it to 0.911 (P = 0.3; net reclassification improvement (NRI): 10.2%, P = 0.001). In people ≥50 years of age, the C-statistics without and with the score were 0.883 and 0.884 (P = 0.2; NRI: 0.4%). The risk per risk allele was higher in people <50 than ≥50 years of age (24 vs. 11%; P value for age interaction = 0.02). Conclusions Knowledge of common genetic variation appropriately reclassifies younger people for type 2 diabetes risk beyond clinical risk factors but not older people."xsd:string
http://purl.uniprot.org/citations/20889853	http://purl.org/dc/terms/identifier	"doi:10.2337/dc10-1265"xsd:string
http://purl.uniprot.org/citations/20889853	http://purl.uniprot.org/core/author	"Dupuis J."xsd:string
http://purl.uniprot.org/citations/20889853	http://purl.uniprot.org/core/author	"Florez J.C."xsd:string
http://purl.uniprot.org/citations/20889853	http://purl.uniprot.org/core/author	"Fox C.S."xsd:string
http://purl.uniprot.org/citations/20889853	http://purl.uniprot.org/core/author	"Cupples L.A."xsd:string
http://purl.uniprot.org/citations/20889853	http://purl.uniprot.org/core/author	"Meigs J.B."xsd:string
http://purl.uniprot.org/citations/20889853	http://purl.uniprot.org/core/author	"D'Agostino R.B. Sr."xsd:string
http://purl.uniprot.org/citations/20889853	http://purl.uniprot.org/core/author	"Manning A.K."xsd:string
http://purl.uniprot.org/citations/20889853	http://purl.uniprot.org/core/author	"Pencina M.J."xsd:string
http://purl.uniprot.org/citations/20889853	http://purl.uniprot.org/core/author	"Grant R.W."xsd:string
http://purl.uniprot.org/citations/20889853	http://purl.uniprot.org/core/author	"Shrader P."xsd:string
http://purl.uniprot.org/citations/20889853	http://purl.uniprot.org/core/author	"de Miguel-Yanes J.M."xsd:string
http://purl.uniprot.org/citations/20889853	http://purl.uniprot.org/core/date	"2011"xsd:gYear
http://purl.uniprot.org/citations/20889853	http://purl.uniprot.org/core/name	"Diabetes Care"xsd:string
http://purl.uniprot.org/citations/20889853	http://purl.uniprot.org/core/pages	"121-125"xsd:string
http://purl.uniprot.org/citations/20889853	http://purl.uniprot.org/core/title	"Genetic risk reclassification for type 2 diabetes by age below or above 50 years using 40 type 2 diabetes risk single nucleotide polymorphisms."xsd:string
http://purl.uniprot.org/citations/20889853	http://purl.uniprot.org/core/volume	"34"xsd:string
http://purl.uniprot.org/citations/20889853	http://www.w3.org/2004/02/skos/core#exactMatch	http://purl.uniprot.org/pubmed/20889853
http://purl.uniprot.org/citations/20889853	http://xmlns.com/foaf/0.1/primaryTopicOf	https://pubmed.ncbi.nlm.nih.gov/20889853
http://purl.uniprot.org/uniprot/#_A0A0D9SGH8-mappedCitation-20889853	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/20889853
http://purl.uniprot.org/uniprot/#_A0A0A0MT79-mappedCitation-20889853	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/20889853
http://purl.uniprot.org/uniprot/#_A0A0A0MTL7-mappedCitation-20889853	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/20889853
http://purl.uniprot.org/uniprot/#_A0A087WXP3-mappedCitation-20889853	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/20889853