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| http://purl.uniprot.org/citations/20890309 | http://www.w3.org/2000/01/rdf-schema#comment | "Growth factor receptor-bound protein 14 (Grb14) is an adaptor protein that is involved in receptor tyrosine kinase signalling. In this study, we report that Grb14 interacts with the rod photoreceptor-specific cyclic-nucleotide-gated channel alpha subunit (CNGA1) and decreases its affinity for cyclic guanosine monophosphate. Channel modulation is controlled by direct binding of the Grb14 Ras-associating domain with the carboxy-terminal region of CNGA1. We observed that the channel remains open in Grb14(-/-) mice that are exposed to light, suggesting that Grb14 is a normal physiological modulator of CNG channel function in vivo."xsd:string |
| http://purl.uniprot.org/citations/20890309 | http://purl.org/dc/terms/identifier | "doi:10.1038/embor.2010.142"xsd:string |
| http://purl.uniprot.org/citations/20890309 | http://purl.uniprot.org/core/author | "Daly R.J."xsd:string |
| http://purl.uniprot.org/citations/20890309 | http://purl.uniprot.org/core/author | "Gupta V.K."xsd:string |
| http://purl.uniprot.org/citations/20890309 | http://purl.uniprot.org/core/author | "Rajala R.V."xsd:string |
| http://purl.uniprot.org/citations/20890309 | http://purl.uniprot.org/core/author | "Rajala A."xsd:string |
| http://purl.uniprot.org/citations/20890309 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20890309 | http://purl.uniprot.org/core/name | "EMBO Rep"xsd:string |
| http://purl.uniprot.org/citations/20890309 | http://purl.uniprot.org/core/pages | "861-867"xsd:string |
| http://purl.uniprot.org/citations/20890309 | http://purl.uniprot.org/core/title | "Growth factor receptor-bound protein 14: a new modulator of photoreceptor-specific cyclic-nucleotide-gated channel."xsd:string |
| http://purl.uniprot.org/citations/20890309 | http://purl.uniprot.org/core/volume | "11"xsd:string |
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