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| http://purl.uniprot.org/citations/20920789 | http://www.w3.org/2000/01/rdf-schema#comment | "Establishing synaptic connections often involves the activity-dependent withdrawal of off-target contacts. We describe an in vivo role for temporally patterned electrical activity, voltage-gated calcium channels, and CaMKII in modulating the response of Drosophila motoneurons to the chemorepellent Sema-2a during synaptic refinement. Mutations affecting the Sema-2a ligand, the plexin B receptor (plexB), the voltage-gated Ca(v)2.1 calcium channel (cac), or the voltage-gated Na(v)1 sodium channel (mle(nap-ts);tipE) each result in ectopic neuromuscular contacts. Sema-2a interacts genetically with both of the channel mutations. The cac phenotype is enhanced by the Sema-2a mutation and is suppressed by either plexB overexpression or patterned, low-frequency (0.01 Hz) bouts of electrical activity in the embryo. The calcium-dependent suppression of ectopic contacts also depends on the downstream activation of CaMKII. These results indicate a role for patterned electrical activity and presynaptic calcium signaling, acting through CaMKII, in modulating a retrograde signal during the refinement of synaptic connections."xsd:string |
| http://purl.uniprot.org/citations/20920789 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.neuron.2010.09.005"xsd:string |
| http://purl.uniprot.org/citations/20920789 | http://purl.uniprot.org/core/author | "Yoon K.S."xsd:string |
| http://purl.uniprot.org/citations/20920789 | http://purl.uniprot.org/core/author | "Keshishian H."xsd:string |
| http://purl.uniprot.org/citations/20920789 | http://purl.uniprot.org/core/author | "Carrillo R.A."xsd:string |
| http://purl.uniprot.org/citations/20920789 | http://purl.uniprot.org/core/author | "Olsen D.P."xsd:string |
| http://purl.uniprot.org/citations/20920789 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20920789 | http://purl.uniprot.org/core/name | "Neuron"xsd:string |
| http://purl.uniprot.org/citations/20920789 | http://purl.uniprot.org/core/pages | "32-44"xsd:string |
| http://purl.uniprot.org/citations/20920789 | http://purl.uniprot.org/core/title | "Presynaptic activity and CaMKII modulate retrograde semaphorin signaling and synaptic refinement."xsd:string |
| http://purl.uniprot.org/citations/20920789 | http://purl.uniprot.org/core/volume | "68"xsd:string |
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