| http://purl.uniprot.org/citations/20921362 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20921362 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20921362 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Citation |
| http://purl.uniprot.org/citations/20921362 | http://www.w3.org/2000/01/rdf-schema#comment | "Trichloroethylene (TCE) is one of the most widespread environmental contaminants, which is metabolized to N-acetyl-S-1,2-dichlorovinyl-L-cysteine (NA-DCVC) before being excreted in the urine. Alternatively, NA-DCVC can be deacetylated by aminoacylase 3 (AA3), an enzyme that is highly expressed in the kidney, liver, and brain. NA-DCVC deacetylation initiates the transformation into toxic products that ultimately causes acute renal failure. AA3 inhibition is therefore a target of interest to prevent TCE induced nephrotoxicity. Here we report the crystal structure of recombinant mouse AA3 (mAA3) in the presence of its acetate byproduct and two substrates: N(α)-acetyl-L-tyrosine and NA-DCVC. These structures, in conjunction with biochemical data, indicated that AA3 mediates substrate specificity through van der Waals interactions providing a dynamic interaction interface, which facilitates a diverse range of substrates."xsd:string |
| http://purl.uniprot.org/citations/20921362 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.1006687107"xsd:string |
| http://purl.uniprot.org/citations/20921362 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.1006687107"xsd:string |
| http://purl.uniprot.org/citations/20921362 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.1006687107"xsd:string |
| http://purl.uniprot.org/citations/20921362 | http://purl.uniprot.org/core/author | "Abramson J."xsd:string |
| http://purl.uniprot.org/citations/20921362 | http://purl.uniprot.org/core/author | "Abramson J."xsd:string |
| http://purl.uniprot.org/citations/20921362 | http://purl.uniprot.org/core/author | "Sawaya M.R."xsd:string |
| http://purl.uniprot.org/citations/20921362 | http://purl.uniprot.org/core/author | "Sawaya M.R."xsd:string |
| http://purl.uniprot.org/citations/20921362 | http://purl.uniprot.org/core/author | "Abuladze N."xsd:string |
| http://purl.uniprot.org/citations/20921362 | http://purl.uniprot.org/core/author | "Abuladze N."xsd:string |
| http://purl.uniprot.org/citations/20921362 | http://purl.uniprot.org/core/author | "Hsieh J.M."xsd:string |
| http://purl.uniprot.org/citations/20921362 | http://purl.uniprot.org/core/author | "Hsieh J.M."xsd:string |
| http://purl.uniprot.org/citations/20921362 | http://purl.uniprot.org/core/author | "Kurtz I."xsd:string |
| http://purl.uniprot.org/citations/20921362 | http://purl.uniprot.org/core/author | "Kurtz I."xsd:string |
| http://purl.uniprot.org/citations/20921362 | http://purl.uniprot.org/core/author | "Magilnick N."xsd:string |
| http://purl.uniprot.org/citations/20921362 | http://purl.uniprot.org/core/author | "Magilnick N."xsd:string |
| http://purl.uniprot.org/citations/20921362 | http://purl.uniprot.org/core/author | "Pushkin A."xsd:string |
| http://purl.uniprot.org/citations/20921362 | http://purl.uniprot.org/core/author | "Pushkin A."xsd:string |
| http://purl.uniprot.org/citations/20921362 | http://purl.uniprot.org/core/author | "Tsirulnikov K."xsd:string |
| http://purl.uniprot.org/citations/20921362 | http://purl.uniprot.org/core/author | "Tsirulnikov K."xsd:string |
| http://purl.uniprot.org/citations/20921362 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20921362 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |