| http://purl.uniprot.org/citations/20921392 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20921392 | http://www.w3.org/2000/01/rdf-schema#comment | "Translational repression mediated by RNA-binding proteins or micro RNAs has emerged as a major regulatory mechanism for fine-tuning important biological processes. In Caenorhabditis elegans, translational repression of the key sex-determination gene tra-2 (tra, transformer) is controlled by a 28-nucleotide repeat element, the TRA-2/GLI element (TGE), located in its 3' untranslated region (UTR). Mutations that disrupt TGE or the germline-specific TGE-binding factor GLD-1 increase TRA-2 protein expression and inhibit sperm production in hermaphrodites. Here we report the characterization of the sup-26 gene, which regulates sex determination in the soma and encodes an RNA recognition motif (RRM)-containing protein. We show that SUP-26 regulates the level of the TRA-2 protein through TGE in vivo and binds directly to TGE in vitro through its RRM domain. Interestingly, SUP-26 associates with poly(A)-binding protein 1 (PAB-1) in vivo and may repress tra-2 expression by inhibiting the translation-stimulating activity of PAB-1. Taken together, our results provide further insight into how mRNA-binding factors repress translation and modulate sexual development in different tissues of C. elegans."xsd:string |
| http://purl.uniprot.org/citations/20921392 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.1004513107"xsd:string |
| http://purl.uniprot.org/citations/20921392 | http://purl.uniprot.org/core/author | "Yu J.S."xsd:string |
| http://purl.uniprot.org/citations/20921392 | http://purl.uniprot.org/core/author | "Chen J.T."xsd:string |
| http://purl.uniprot.org/citations/20921392 | http://purl.uniprot.org/core/author | "Xue D."xsd:string |
| http://purl.uniprot.org/citations/20921392 | http://purl.uniprot.org/core/author | "Mapes J."xsd:string |
| http://purl.uniprot.org/citations/20921392 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20921392 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/20921392 | http://purl.uniprot.org/core/pages | "18022-18027"xsd:string |
| http://purl.uniprot.org/citations/20921392 | http://purl.uniprot.org/core/title | "Somatic sex determination in Caenorhabditis elegans is modulated by SUP-26 repression of tra-2 translation."xsd:string |
| http://purl.uniprot.org/citations/20921392 | http://purl.uniprot.org/core/volume | "107"xsd:string |
| http://purl.uniprot.org/citations/20921392 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20921392 |
| http://purl.uniprot.org/citations/20921392 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20921392 |
| http://purl.uniprot.org/uniprot/Q21900#attribution-0879981C2684E53AB1CC6AED6C6B40BC | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/20921392 |
| http://purl.uniprot.org/uniprot/Q21900#attribution-3D4E7E6086B33E1661DE34B5872F1494 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/20921392 |
| http://purl.uniprot.org/uniprot/D5MCQ3#attribution-0879981C2684E53AB1CC6AED6C6B40BC | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/20921392 |
| http://purl.uniprot.org/uniprot/D5MCQ3#attribution-3D4E7E6086B33E1661DE34B5872F1494 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/20921392 |
| http://purl.uniprot.org/uniprot/D5MCQ2#attribution-0879981C2684E53AB1CC6AED6C6B40BC | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/20921392 |
| http://purl.uniprot.org/uniprot/D5MCQ2#attribution-3D4E7E6086B33E1661DE34B5872F1494 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/20921392 |
| http://purl.uniprot.org/uniprot/D5MCQ6#attribution-0879981C2684E53AB1CC6AED6C6B40BC | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/20921392 |
| http://purl.uniprot.org/uniprot/D5MCQ6#attribution-3D4E7E6086B33E1661DE34B5872F1494 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/20921392 |
| http://purl.uniprot.org/uniprot/D5MCQ5#attribution-0879981C2684E53AB1CC6AED6C6B40BC | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/20921392 |
| http://purl.uniprot.org/uniprot/D5MCQ5#attribution-3D4E7E6086B33E1661DE34B5872F1494 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/20921392 |
| http://purl.uniprot.org/uniprot/D5MCR3#attribution-0879981C2684E53AB1CC6AED6C6B40BC | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/20921392 |