| http://purl.uniprot.org/citations/20921409 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20921409 | http://www.w3.org/2000/01/rdf-schema#comment | "Phagocytosis of apoptotic cells requires recognition of cell corpses followed by internalization and enclosure within plasma membrane-derived phagosomes. Phagosomes undergo maturation to generate phagolysosomes in which cell corpses are degraded; however, regulation of the maturation process is poorly understood. Here, we identified Rab GTPase 14, which regulates apoptotic cell degradation in Caenorhabditis elegans. rab-14 mutants accumulate many persistent cell corpses owing to defective cell corpse clearance. Loss of rab-14 function affects several steps of phagosome maturation including phagosomal acidification and phagolysosome formation. RAB-14 and UNC-108/RAB2 are recruited to phagosomes at a similar stage and function redundantly to regulate phagosome maturation. Three Rabs, RAB-14, UNC-108/RAB2, and RAB-7, act in sequential steps to control phagolysosome formation. RAB-14 and UNC-108 recruit lysosomes, whereas RAB-7 mediates fusion of lysosomes to phagosomes. Our data reveal the sequential action of Rab GTPases in regulating tethering, docking, and fusion of lysosomes to apoptotic cell-containing phagosomes."xsd:string |
| http://purl.uniprot.org/citations/20921409 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.1008946107"xsd:string |
| http://purl.uniprot.org/citations/20921409 | http://purl.uniprot.org/core/author | "Jiang S."xsd:string |
| http://purl.uniprot.org/citations/20921409 | http://purl.uniprot.org/core/author | "Zhang J."xsd:string |
| http://purl.uniprot.org/citations/20921409 | http://purl.uniprot.org/core/author | "Wang X."xsd:string |
| http://purl.uniprot.org/citations/20921409 | http://purl.uniprot.org/core/author | "Hu T."xsd:string |
| http://purl.uniprot.org/citations/20921409 | http://purl.uniprot.org/core/author | "Guo P."xsd:string |
| http://purl.uniprot.org/citations/20921409 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20921409 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/20921409 | http://purl.uniprot.org/core/pages | "18016-18021"xsd:string |
| http://purl.uniprot.org/citations/20921409 | http://purl.uniprot.org/core/title | "Sequential action of Caenorhabditis elegans Rab GTPases regulates phagolysosome formation during apoptotic cell degradation."xsd:string |
| http://purl.uniprot.org/citations/20921409 | http://purl.uniprot.org/core/volume | "107"xsd:string |
| http://purl.uniprot.org/citations/20921409 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20921409 |
| http://purl.uniprot.org/citations/20921409 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20921409 |
| http://purl.uniprot.org/uniprot/Q10916#attribution-2949B3C7ED3D57D0CD3712FAF0055562 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/20921409 |
| http://purl.uniprot.org/uniprot/P43510#attribution-2949B3C7ED3D57D0CD3712FAF0055562 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/20921409 |
| http://purl.uniprot.org/uniprot/Q17778#attribution-2949B3C7ED3D57D0CD3712FAF0055562 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/20921409 |
| http://purl.uniprot.org/uniprot/O01577#attribution-2949B3C7ED3D57D0CD3712FAF0055562 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/20921409 |
| http://purl.uniprot.org/uniprot/O01577#attribution-37FC2B830225EF639ADECBF9890EACC2 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/20921409 |
| http://purl.uniprot.org/uniprot/Q23146#attribution-2949B3C7ED3D57D0CD3712FAF0055562 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/20921409 |
| http://purl.uniprot.org/uniprot/Q23146#attribution-37FC2B830225EF639ADECBF9890EACC2 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/20921409 |
| http://purl.uniprot.org/uniprot/P91857#attribution-2949B3C7ED3D57D0CD3712FAF0055562 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/20921409 |
| http://purl.uniprot.org/uniprot/P91857#attribution-37FC2B830225EF639ADECBF9890EACC2 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/20921409 |
| http://purl.uniprot.org/uniprot/Q93874#attribution-2949B3C7ED3D57D0CD3712FAF0055562 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/20921409 |