| http://purl.uniprot.org/citations/20923696 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20923696 | http://www.w3.org/2000/01/rdf-schema#comment | "Obesity is associated with increased risk of diabetes, cardiovascular disease and several types of cancers. The hypothalamus is a region of the brain critical in the regulation of body weight. One of the critical and best studied hypothalamic circuits is comprised of the melanocortinergic orexigenic agouti-related protein (AgRP) and anorexigenic α-melanocyte stimulating hormone (α-MSH) neurons. These neurons project axons to the same hypothalamic target neurons and balance each other's activity leading to body weight regulation. We previously showed that the brain proteoglycan syndecan-3 regulates feeding behavior and body weight, and syndecan-3 null (SDC-3(-/-)) mice are lean and obesity resistant. Here we show that the melanocortin agonist Melanotan II (MTII) potently suppresses food intake and activates the hypothalamic paraventricular nuclei (PVN) in SDC-3(-/-) mice based on c-fos immunoreactivity. Interestingly, we determined that the AgRP neuropeptide is reduced in the PVN of SDC-3(-/-) mice compared to wild type mice. In contrast, neuropeptide Y, coexpressed in the AgRP neuron, is not differentially expressed nor is the counteracting neuropeptide α-MSH. These findings are unprecedented and indicate that AgRP protein localization can be selectively regulated within the hypothalamus resulting in altered neuropeptide response and tone."xsd:string |
| http://purl.uniprot.org/citations/20923696 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.neuroscience.2010.09.060"xsd:string |
| http://purl.uniprot.org/citations/20923696 | http://purl.uniprot.org/core/author | "Zhu J."xsd:string |
| http://purl.uniprot.org/citations/20923696 | http://purl.uniprot.org/core/author | "Zheng Q."xsd:string |
| http://purl.uniprot.org/citations/20923696 | http://purl.uniprot.org/core/author | "Horvath T.L."xsd:string |
| http://purl.uniprot.org/citations/20923696 | http://purl.uniprot.org/core/author | "Reizes O."xsd:string |
| http://purl.uniprot.org/citations/20923696 | http://purl.uniprot.org/core/author | "Clegg D.J."xsd:string |
| http://purl.uniprot.org/citations/20923696 | http://purl.uniprot.org/core/author | "Borok E."xsd:string |
| http://purl.uniprot.org/citations/20923696 | http://purl.uniprot.org/core/author | "Benoit S.C."xsd:string |
| http://purl.uniprot.org/citations/20923696 | http://purl.uniprot.org/core/author | "Shanabrough M."xsd:string |
| http://purl.uniprot.org/citations/20923696 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20923696 | http://purl.uniprot.org/core/name | "Neuroscience"xsd:string |
| http://purl.uniprot.org/citations/20923696 | http://purl.uniprot.org/core/pages | "1032-1040"xsd:string |
| http://purl.uniprot.org/citations/20923696 | http://purl.uniprot.org/core/title | "Enhanced anorexigenic signaling in lean obesity resistant syndecan-3 null mice."xsd:string |
| http://purl.uniprot.org/citations/20923696 | http://purl.uniprot.org/core/volume | "171"xsd:string |
| http://purl.uniprot.org/citations/20923696 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20923696 |
| http://purl.uniprot.org/citations/20923696 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20923696 |
| http://purl.uniprot.org/uniprot/#_B1ASF6-mappedCitation-20923696 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20923696 |
| http://purl.uniprot.org/uniprot/#_Q64519-mappedCitation-20923696 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20923696 |
| http://purl.uniprot.org/uniprot/Q64519 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/20923696 |
| http://purl.uniprot.org/uniprot/B1ASF6 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/20923696 |