| http://purl.uniprot.org/citations/20924113 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20924113 | http://www.w3.org/2000/01/rdf-schema#comment | "Hypoxia within the tumor microenvironment promotes angiogenesis, metabolic reprogramming, and tumor progression. In addition to activating hypoxia-inducible factor-1α (HIF-1α), cells also respond to hypoxia by globally inhibiting protein synthesis via serine 51 phosphorylation of translation eukaryotic initiation factor 2α (eIF2α). In this study, we investigated potential roles for stress-activated eIF2α kinases in regulation of HIF-1α. Our investigations revealed that the double-stranded RNA-dependent protein kinase R (PKR) plays a significant role in suppressing HIF-1α expression, acting specifically at the level of transcription. HIF-1α transcriptional repression by PKR was sufficient to impair the hypoxia-induced accumulation of HIF-1α and transcriptional induction of HIF-1α-dependent target genes. Inhibition of HIF-1A transcription by PKR was independent of eIF2α phosphorylation but dependent on inhibition of the signal transducer and activator of transcription 3 (Stat3). Furthermore, HIF-1A repression required the T-cell protein tyrosine phosphatase, which acts downstream of PKR, to suppress Stat3. Our findings reveal a novel tumor suppressor function for PKR, which inhibits HIF-1α expression through Stat3 but is independent of eIF2α phosphorylation."xsd:string |
| http://purl.uniprot.org/citations/20924113 | http://purl.org/dc/terms/identifier | "doi:10.1158/0008-5472.can-10-0215"xsd:string |
| http://purl.uniprot.org/citations/20924113 | http://purl.uniprot.org/core/author | "Li S."xsd:string |
| http://purl.uniprot.org/citations/20924113 | http://purl.uniprot.org/core/author | "Simos G."xsd:string |
| http://purl.uniprot.org/citations/20924113 | http://purl.uniprot.org/core/author | "Paraskeva E."xsd:string |
| http://purl.uniprot.org/citations/20924113 | http://purl.uniprot.org/core/author | "Koromilas A.E."xsd:string |
| http://purl.uniprot.org/citations/20924113 | http://purl.uniprot.org/core/author | "Muaddi H."xsd:string |
| http://purl.uniprot.org/citations/20924113 | http://purl.uniprot.org/core/author | "Papadakis A.I."xsd:string |
| http://purl.uniprot.org/citations/20924113 | http://purl.uniprot.org/core/author | "Peidis P."xsd:string |
| http://purl.uniprot.org/citations/20924113 | http://purl.uniprot.org/core/author | "Pantopoulos K."xsd:string |
| http://purl.uniprot.org/citations/20924113 | http://purl.uniprot.org/core/author | "Raptis L."xsd:string |
| http://purl.uniprot.org/citations/20924113 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20924113 | http://purl.uniprot.org/core/name | "Cancer Res"xsd:string |
| http://purl.uniprot.org/citations/20924113 | http://purl.uniprot.org/core/pages | "7820-7829"xsd:string |
| http://purl.uniprot.org/citations/20924113 | http://purl.uniprot.org/core/title | "eIF2{alpha} Kinase PKR modulates the hypoxic response by Stat3-dependent transcriptional suppression of HIF-1{alpha}."xsd:string |
| http://purl.uniprot.org/citations/20924113 | http://purl.uniprot.org/core/volume | "70"xsd:string |
| http://purl.uniprot.org/citations/20924113 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20924113 |
| http://purl.uniprot.org/citations/20924113 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20924113 |
| http://purl.uniprot.org/uniprot/#_A0A0R4J1Y1-mappedCitation-20924113 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20924113 |
| http://purl.uniprot.org/uniprot/#_A2AUL9-mappedCitation-20924113 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20924113 |
| http://purl.uniprot.org/uniprot/#_A2AUM0-mappedCitation-20924113 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20924113 |
| http://purl.uniprot.org/uniprot/#_A2AUM1-mappedCitation-20924113 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20924113 |
| http://purl.uniprot.org/uniprot/#_A2AUM2-mappedCitation-20924113 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20924113 |
| http://purl.uniprot.org/uniprot/#_E9QQ30-mappedCitation-20924113 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20924113 |