| http://purl.uniprot.org/citations/20926789 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20926789 | http://www.w3.org/2000/01/rdf-schema#comment | "The T cell-driven airway inflammation in chronic asthma is uninhibited and sustained. We examined the resistance of T cells from asthmatic patients against suppression by TGF-β, IL-10 and glucocorticoids and explored its signaling mechanism. CD4(+)CD25(-) T cells from allergic asthmatic subjects demonstrated increased TCR-stimulated proliferation as compared with healthy and chronic obstructive pulmonary disease controls. This proliferation was resistant to inhibition by TGF-β, IL-10, and dexamethasone and to anergy induction. CD4 T cells from asthmatic patients, but not chronic obstructive pulmonary disease, allergic rhinitis, and healthy subjects, showed increased expression of MEK1, heightened phosphorylation of ERK1/2, and increased levels of c-Fos. IL-2 and IL-4 stimulated the expression of MEK1 and c-Fos and induced T cell resistance. The inhibition of MEK1 reversed, whereas induced expression of c-Fos and JunB promoted T cell resistance against TGF-β- and IL-10-mediated suppression. We have uncovered an IL-2- and IL-4-driven MEK1 induction mechanism that results in heightened ERK1/2 activation in asthmatic T cells and make them resistant to certain inhibitory mechanisms."xsd:string |
| http://purl.uniprot.org/citations/20926789 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.1000690"xsd:string |
| http://purl.uniprot.org/citations/20926789 | http://purl.uniprot.org/core/author | "Alam R."xsd:string |
| http://purl.uniprot.org/citations/20926789 | http://purl.uniprot.org/core/author | "Guo L."xsd:string |
| http://purl.uniprot.org/citations/20926789 | http://purl.uniprot.org/core/author | "Liang Q."xsd:string |
| http://purl.uniprot.org/citations/20926789 | http://purl.uniprot.org/core/author | "Karim Z."xsd:string |
| http://purl.uniprot.org/citations/20926789 | http://purl.uniprot.org/core/author | "Leung D.Y."xsd:string |
| http://purl.uniprot.org/citations/20926789 | http://purl.uniprot.org/core/author | "Gorska M.M."xsd:string |
| http://purl.uniprot.org/citations/20926789 | http://purl.uniprot.org/core/author | "Gogate S."xsd:string |
| http://purl.uniprot.org/citations/20926789 | http://purl.uniprot.org/core/author | "Hanifi A."xsd:string |
| http://purl.uniprot.org/citations/20926789 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20926789 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/20926789 | http://purl.uniprot.org/core/pages | "5704-5713"xsd:string |
| http://purl.uniprot.org/citations/20926789 | http://purl.uniprot.org/core/title | "IL-2 and IL-4 stimulate MEK1 expression and contribute to T cell resistance against suppression by TGF-beta and IL-10 in asthma."xsd:string |
| http://purl.uniprot.org/citations/20926789 | http://purl.uniprot.org/core/volume | "185"xsd:string |
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