| http://purl.uniprot.org/citations/20935224 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20935224 | http://www.w3.org/2000/01/rdf-schema#comment | "Response to immunocytokine (IC) therapy is dependent on natural killer cells in murine neuroblastoma (NBL) models. Furthermore, killer immunoglobulin-like receptor (KIR)/KIR-ligand mismatch is associated with improved outcome to autologous stem cell transplant for NBL. Additionally, clinical antitumor response to monoclonal antibodies has been associated with specific polymorphic-FcγR alleles. Relapsed/refractory NBL patients received the hu14.18-IL2 IC (humanized anti-GD2 monoclonal antibody linked to human IL2) in a Children's Oncology Group phase II trial. In this report, these patients were genotyped for KIR, HLA, and FcR alleles to determine whether KIR receptor-ligand mismatch or specific FcγR alleles were associated with antitumor response. DNA samples were available for 38 of 39 patients enrolled: 24 were found to have autologous KIR/KIR-ligand mismatch; 14 were matched. Of the 24 mismatched patients, 7 experienced either complete response or improvement of their disease after IC therapy. There was no response or comparable improvement of disease in patients who were matched. Thus KIR/KIR-ligand mismatch was associated with response/improvement to IC (P = 0.03). There was a trend toward patients with the FcγR2A 131-H/H genotype showing a higher response rate than other FcγR2A genotypes (P = 0.06). These analyses indicate that response or improvement of relapsed/refractory NBL patients after IC treatment is associated with autologous KIR/KIR-ligand mismatch, consistent with a role for natural killer cells in this clinical response."xsd:string |
| http://purl.uniprot.org/citations/20935224 | http://purl.org/dc/terms/identifier | "doi:10.1158/0008-5472.can-10-2211"xsd:string |
| http://purl.uniprot.org/citations/20935224 | http://purl.uniprot.org/core/author | "Kim K."xsd:string |
| http://purl.uniprot.org/citations/20935224 | http://purl.uniprot.org/core/author | "Gan J."xsd:string |
| http://purl.uniprot.org/citations/20935224 | http://purl.uniprot.org/core/author | "Yang R."xsd:string |
| http://purl.uniprot.org/citations/20935224 | http://purl.uniprot.org/core/author | "Seo S."xsd:string |
| http://purl.uniprot.org/citations/20935224 | http://purl.uniprot.org/core/author | "London W.B."xsd:string |
| http://purl.uniprot.org/citations/20935224 | http://purl.uniprot.org/core/author | "Maris J.M."xsd:string |
| http://purl.uniprot.org/citations/20935224 | http://purl.uniprot.org/core/author | "Reisfeld R.A."xsd:string |
| http://purl.uniprot.org/citations/20935224 | http://purl.uniprot.org/core/author | "Gillies S.D."xsd:string |
| http://purl.uniprot.org/citations/20935224 | http://purl.uniprot.org/core/author | "Seeger R.C."xsd:string |
| http://purl.uniprot.org/citations/20935224 | http://purl.uniprot.org/core/author | "Lorentzen D."xsd:string |
| http://purl.uniprot.org/citations/20935224 | http://purl.uniprot.org/core/author | "Kolesar J."xsd:string |
| http://purl.uniprot.org/citations/20935224 | http://purl.uniprot.org/core/author | "Shusterman S."xsd:string |
| http://purl.uniprot.org/citations/20935224 | http://purl.uniprot.org/core/author | "Sondel P.M."xsd:string |
| http://purl.uniprot.org/citations/20935224 | http://purl.uniprot.org/core/author | "DeSantes K.B."xsd:string |
| http://purl.uniprot.org/citations/20935224 | http://purl.uniprot.org/core/author | "Delgado D.C."xsd:string |
| http://purl.uniprot.org/citations/20935224 | http://purl.uniprot.org/core/author | "Gadbaw B."xsd:string |
| http://purl.uniprot.org/citations/20935224 | http://purl.uniprot.org/core/author | "Hank J.A."xsd:string |
| http://purl.uniprot.org/citations/20935224 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20935224 | http://purl.uniprot.org/core/name | "Cancer Res"xsd:string |
| http://purl.uniprot.org/citations/20935224 | http://purl.uniprot.org/core/pages | "9554-9561"xsd:string |
| http://purl.uniprot.org/citations/20935224 | http://purl.uniprot.org/core/title | "Genotypes of NK cell KIR receptors, their ligands, and Fcgamma receptors in the response of neuroblastoma patients to Hu14.18-IL2 immunotherapy."xsd:string |
| http://purl.uniprot.org/citations/20935224 | http://purl.uniprot.org/core/volume | "70"xsd:string |