| http://purl.uniprot.org/citations/20935258 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20935258 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20935258 | http://www.w3.org/2000/01/rdf-schema#comment | "Extracellular protein interactions are crucial to the development of multicellular organisms because they initiate signaling pathways and enable cellular recognition cues. Despite their importance, extracellular protein interactions are often under-represented in large scale protein interaction data sets because most high throughput assays are not designed to detect low affinity extracellular interactions. Due to the lack of a comprehensive data set, the evolution of extracellular signaling pathways has remained largely a mystery. We investigated this question using a combined data set of physical pairwise interactions between zebrafish extracellular proteins, mainly from the immunoglobulin superfamily and leucine-rich repeat families, and their spatiotemporal expression profiles. We took advantage of known homology between proteins to estimate the relative rates of changes of four parameters after gene duplication, namely extracellular protein interaction, expression pattern, and the divergence of extracellular and intracellular protein sequences. We showed that change in expression profile is a major contributor to the evolution of signaling pathways followed by divergence in intracellular protein sequence, whereas extracellular sequence and interaction profiles were relatively more conserved. Rapidly evolving expression profiles will eventually drive other parameters to diverge more quickly because differentially expressed proteins get exposed to different environments and potential binding partners. This allows homologous extracellular receptors to attain specialized functions and become specific to tissues and/or developmental stages."xsd:string |
| http://purl.uniprot.org/citations/20935258 | http://purl.org/dc/terms/identifier | "doi:10.1074/mcp.m110.003020"xsd:string |
| http://purl.uniprot.org/citations/20935258 | http://purl.org/dc/terms/identifier | "doi:10.1074/mcp.m110.003020"xsd:string |
| http://purl.uniprot.org/citations/20935258 | http://purl.uniprot.org/core/author | "Martin S."xsd:string |
| http://purl.uniprot.org/citations/20935258 | http://purl.uniprot.org/core/author | "Martin S."xsd:string |
| http://purl.uniprot.org/citations/20935258 | http://purl.uniprot.org/core/author | "Teichmann S.A."xsd:string |
| http://purl.uniprot.org/citations/20935258 | http://purl.uniprot.org/core/author | "Teichmann S.A."xsd:string |
| http://purl.uniprot.org/citations/20935258 | http://purl.uniprot.org/core/author | "Wright G.J."xsd:string |
| http://purl.uniprot.org/citations/20935258 | http://purl.uniprot.org/core/author | "Wright G.J."xsd:string |
| http://purl.uniprot.org/citations/20935258 | http://purl.uniprot.org/core/author | "Thisse B."xsd:string |
| http://purl.uniprot.org/citations/20935258 | http://purl.uniprot.org/core/author | "Thisse B."xsd:string |
| http://purl.uniprot.org/citations/20935258 | http://purl.uniprot.org/core/author | "Thisse C."xsd:string |
| http://purl.uniprot.org/citations/20935258 | http://purl.uniprot.org/core/author | "Thisse C."xsd:string |
| http://purl.uniprot.org/citations/20935258 | http://purl.uniprot.org/core/author | "Charoensawan V."xsd:string |
| http://purl.uniprot.org/citations/20935258 | http://purl.uniprot.org/core/author | "Charoensawan V."xsd:string |
| http://purl.uniprot.org/citations/20935258 | http://purl.uniprot.org/core/author | "Sollner C."xsd:string |
| http://purl.uniprot.org/citations/20935258 | http://purl.uniprot.org/core/author | "Sollner C."xsd:string |
| http://purl.uniprot.org/citations/20935258 | http://purl.uniprot.org/core/author | "Adryan B."xsd:string |
| http://purl.uniprot.org/citations/20935258 | http://purl.uniprot.org/core/author | "Adryan B."xsd:string |
| http://purl.uniprot.org/citations/20935258 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20935258 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20935258 | http://purl.uniprot.org/core/name | "Mol. Cell. Proteomics"xsd:string |
| http://purl.uniprot.org/citations/20935258 | http://purl.uniprot.org/core/name | "Mol Cell Proteomics"xsd:string |