http://purl.uniprot.org/citations/20935628 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/20935628 | http://www.w3.org/2000/01/rdf-schema#comment | "Hepatitis C virus (HCV) infection is closely tied to the lipid metabolism of liver cells. Here we identify the triglyceride-synthesizing enzyme diacylglycerol acyltransferase-1 (DGAT1) as a key host factor for HCV infection. DGAT1 interacts with the viral nucleocapsid core and is required for the trafficking of core to lipid droplets. Inhibition of DGAT1 activity or RNAi-mediated knockdown of DGAT1 severely impairs infectious virion production, implicating DGAT1 as a new target for antiviral therapy."xsd:string |
http://purl.uniprot.org/citations/20935628 | http://purl.org/dc/terms/identifier | "doi:10.1038/nm.2238"xsd:string |
http://purl.uniprot.org/citations/20935628 | http://purl.uniprot.org/core/author | "Ott M."xsd:string |
http://purl.uniprot.org/citations/20935628 | http://purl.uniprot.org/core/author | "Hernandez C."xsd:string |
http://purl.uniprot.org/citations/20935628 | http://purl.uniprot.org/core/author | "Herker E."xsd:string |
http://purl.uniprot.org/citations/20935628 | http://purl.uniprot.org/core/author | "Farese R.V. Jr."xsd:string |
http://purl.uniprot.org/citations/20935628 | http://purl.uniprot.org/core/author | "Kaehlcke K."xsd:string |
http://purl.uniprot.org/citations/20935628 | http://purl.uniprot.org/core/author | "Harris C."xsd:string |
http://purl.uniprot.org/citations/20935628 | http://purl.uniprot.org/core/author | "Carpentier A."xsd:string |
http://purl.uniprot.org/citations/20935628 | http://purl.uniprot.org/core/author | "Rosenberg A.R."xsd:string |
http://purl.uniprot.org/citations/20935628 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
http://purl.uniprot.org/citations/20935628 | http://purl.uniprot.org/core/name | "Nat Med"xsd:string |
http://purl.uniprot.org/citations/20935628 | http://purl.uniprot.org/core/pages | "1295-1298"xsd:string |
http://purl.uniprot.org/citations/20935628 | http://purl.uniprot.org/core/title | "Efficient hepatitis C virus particle formation requires diacylglycerol acyltransferase-1."xsd:string |
http://purl.uniprot.org/citations/20935628 | http://purl.uniprot.org/core/volume | "16"xsd:string |
http://purl.uniprot.org/citations/20935628 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20935628 |
http://purl.uniprot.org/citations/20935628 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20935628 |
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