| http://purl.uniprot.org/citations/20935677 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20935677 | http://www.w3.org/2000/01/rdf-schema#comment | "It is prevailingly thought that estrogen signaling is not involved in development of estrogen receptor (ER)-negative breast cancer. However, there is evidence indicating that ovariectomy prevents the development of both ER-positive and -negative breast cancer, suggesting that estrogen signaling is involved in the development of ER-negative breast cancer. Previously, our laboratory cloned a variant of ER-α, ER-α36, and found that ER-α36 mediated nongenomic estrogen signaling and is highly expressed in ER-negative breast cancer cells. In this study, we found that ER-α36 was highly expressed in 10/12 cases of triple-negative breast cancer. We investigated the role of mitogenic estrogen signaling mediated by ER-α36 in malignant growth of triple-negative breast cancer MDA-MB-231 and MDA-MB-436 cells that express high levels of ER-α36 and found that these cells strongly responded to mitogenic estrogen signaling both in vitro and in vivo. Knockdown of ER-α36 expression in these cells using the small hairpin RNA method diminished their responsiveness to estrogen. ER-α36 physically interacted with the EGFR/Src/Shc complex and mediated estrogen-induced phosphorylation of epidermal growth factor receptor (EGFR) and Src. EGFR signaling activated ER-α36 transcription through an AP1 site in the ER-α36 promoter, and ER-α36 expression was able to stabilize EGFR protein. Our results, thus demonstrated that ER-α36 mediates nongenomic estrogen signaling through the EGFR/Src/ERK signaling pathway in ER-negative breast cancer cells and suggested that a subset of ER-negative breast tumors that expresses ER-α36, retains responsiveness to mitogenic estrogen signaling."xsd:string |
| http://purl.uniprot.org/citations/20935677 | http://purl.org/dc/terms/identifier | "doi:10.1038/onc.2010.458"xsd:string |
| http://purl.uniprot.org/citations/20935677 | http://purl.uniprot.org/core/author | "Ding L."xsd:string |
| http://purl.uniprot.org/citations/20935677 | http://purl.uniprot.org/core/author | "Wang Z.Y."xsd:string |
| http://purl.uniprot.org/citations/20935677 | http://purl.uniprot.org/core/author | "Gatalica Z."xsd:string |
| http://purl.uniprot.org/citations/20935677 | http://purl.uniprot.org/core/author | "Zhang X.T."xsd:string |
| http://purl.uniprot.org/citations/20935677 | http://purl.uniprot.org/core/author | "Vranic S."xsd:string |
| http://purl.uniprot.org/citations/20935677 | http://purl.uniprot.org/core/author | "Kang L.G."xsd:string |
| http://purl.uniprot.org/citations/20935677 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/20935677 | http://purl.uniprot.org/core/name | "Oncogene"xsd:string |
| http://purl.uniprot.org/citations/20935677 | http://purl.uniprot.org/core/pages | "770-780"xsd:string |
| http://purl.uniprot.org/citations/20935677 | http://purl.uniprot.org/core/title | "A positive feedback loop of ER-alpha36/EGFR promotes malignant growth of ER-negative breast cancer cells."xsd:string |
| http://purl.uniprot.org/citations/20935677 | http://purl.uniprot.org/core/volume | "30"xsd:string |
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