| http://purl.uniprot.org/citations/20936779 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20936779 | http://www.w3.org/2000/01/rdf-schema#comment | "Mitogen-activated protein kinase (MAPK) pathways form the backbone of signal transduction in the mammalian cell. Here we applied a systematic experimental and computational approach to map 2,269 interactions between human MAPK-related proteins and other cellular machinery and to assemble these data into functional modules. Multiple lines of evidence including conservation with yeast supported a core network of 641 interactions. Using small interfering RNA knockdowns, we observed that approximately one-third of MAPK-interacting proteins modulated MAPK-mediated signaling. We uncovered the Na-H exchanger NHE1 as a potential MAPK scaffold, found links between HSP90 chaperones and MAPK pathways and identified MUC12 as the human analog to the yeast signaling mucin Msb2. This study makes available a large resource of MAPK interactions and clone libraries, and it illustrates a methodology for probing signaling networks based on functional refinement of experimentally derived protein-interaction maps."xsd:string |
| http://purl.uniprot.org/citations/20936779 | http://purl.org/dc/terms/identifier | "doi:10.1038/nmeth.1506"xsd:string |
| http://purl.uniprot.org/citations/20936779 | http://purl.uniprot.org/core/author | "Martin C."xsd:string |
| http://purl.uniprot.org/citations/20936779 | http://purl.uniprot.org/core/author | "Ideker T."xsd:string |
| http://purl.uniprot.org/citations/20936779 | http://purl.uniprot.org/core/author | "White S."xsd:string |
| http://purl.uniprot.org/citations/20936779 | http://purl.uniprot.org/core/author | "Barber D.L."xsd:string |
| http://purl.uniprot.org/citations/20936779 | http://purl.uniprot.org/core/author | "Chiang C.Y."xsd:string |
| http://purl.uniprot.org/citations/20936779 | http://purl.uniprot.org/core/author | "Bell R."xsd:string |
| http://purl.uniprot.org/citations/20936779 | http://purl.uniprot.org/core/author | "Bandyopadhyay S."xsd:string |
| http://purl.uniprot.org/citations/20936779 | http://purl.uniprot.org/core/author | "Chanda S.K."xsd:string |
| http://purl.uniprot.org/citations/20936779 | http://purl.uniprot.org/core/author | "Sahasrabudhe S."xsd:string |
| http://purl.uniprot.org/citations/20936779 | http://purl.uniprot.org/core/author | "Srivastava J."xsd:string |
| http://purl.uniprot.org/citations/20936779 | http://purl.uniprot.org/core/author | "Kurschner C."xsd:string |
| http://purl.uniprot.org/citations/20936779 | http://purl.uniprot.org/core/author | "Gersten M."xsd:string |
| http://purl.uniprot.org/citations/20936779 | http://purl.uniprot.org/core/author | "Smoot M."xsd:string |
| http://purl.uniprot.org/citations/20936779 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20936779 | http://purl.uniprot.org/core/name | "Nat Methods"xsd:string |
| http://purl.uniprot.org/citations/20936779 | http://purl.uniprot.org/core/pages | "801-805"xsd:string |
| http://purl.uniprot.org/citations/20936779 | http://purl.uniprot.org/core/title | "A human MAP kinase interactome."xsd:string |
| http://purl.uniprot.org/citations/20936779 | http://purl.uniprot.org/core/volume | "7"xsd:string |
| http://purl.uniprot.org/citations/20936779 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20936779 |
| http://purl.uniprot.org/citations/20936779 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20936779 |
| http://purl.uniprot.org/uniprot/P62258#attribution-5CF1318A010020121399568D29CBFACB | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/20936779 |
| http://purl.uniprot.org/uniprot/#_P0C0L4-mappedCitation-20936779 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20936779 |