| http://purl.uniprot.org/citations/20937701 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20937701 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20937701 | http://www.w3.org/2000/01/rdf-schema#comment | "A key requirement for Rab function in membrane trafficking is site-specific activation by GDP-GTP exchange factors (GEFs), but the majority of the 63 human Rabs have no known GEF. We have performed a systematic characterization of the 17 human DENN domain proteins and demonstrated that they are specific GEFs for 10 Rabs. DENND1A/1B localize to clathrin patches at the plasma membrane and activate Rab35 in an endocytic pathway trafficking Shiga toxin to the trans-Golgi network. DENND2 GEFs target to actin filaments and control Rab9-dependent trafficking of mannose-6-phosphate receptor to lysosomes. DENND4 GEFs target to a tubular membrane compartment adjacent to the Golgi, where they activate Rab10, which suggests a function in basolateral polarized sorting in epithelial cells that compliments the non-DENN GEF Sec2 acting on Rab8 in apical sorting. DENND1C, DENND3, DENND5A/5B, MTMR5/13, and MADD activate Rab13, Rab12, Rab39, Rab28, and Rab27A/27B, respectively. Together, these findings provide a basis for future studies on Rab regulation and function."xsd:string |
| http://purl.uniprot.org/citations/20937701 | http://purl.org/dc/terms/identifier | "doi:10.1083/jcb.201008051"xsd:string |
| http://purl.uniprot.org/citations/20937701 | http://purl.org/dc/terms/identifier | "doi:10.1083/jcb.201008051"xsd:string |
| http://purl.uniprot.org/citations/20937701 | http://purl.uniprot.org/core/author | "Rigden D.J."xsd:string |
| http://purl.uniprot.org/citations/20937701 | http://purl.uniprot.org/core/author | "Rigden D.J."xsd:string |
| http://purl.uniprot.org/citations/20937701 | http://purl.uniprot.org/core/author | "Barr F.A."xsd:string |
| http://purl.uniprot.org/citations/20937701 | http://purl.uniprot.org/core/author | "Barr F.A."xsd:string |
| http://purl.uniprot.org/citations/20937701 | http://purl.uniprot.org/core/author | "Yoshimura S."xsd:string |
| http://purl.uniprot.org/citations/20937701 | http://purl.uniprot.org/core/author | "Yoshimura S."xsd:string |
| http://purl.uniprot.org/citations/20937701 | http://purl.uniprot.org/core/author | "Gerondopoulos A."xsd:string |
| http://purl.uniprot.org/citations/20937701 | http://purl.uniprot.org/core/author | "Gerondopoulos A."xsd:string |
| http://purl.uniprot.org/citations/20937701 | http://purl.uniprot.org/core/author | "Linford A."xsd:string |
| http://purl.uniprot.org/citations/20937701 | http://purl.uniprot.org/core/author | "Linford A."xsd:string |
| http://purl.uniprot.org/citations/20937701 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20937701 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20937701 | http://purl.uniprot.org/core/name | "J. Cell Biol."xsd:string |
| http://purl.uniprot.org/citations/20937701 | http://purl.uniprot.org/core/name | "J. Cell Biol."xsd:string |
| http://purl.uniprot.org/citations/20937701 | http://purl.uniprot.org/core/pages | "367-381"xsd:string |
| http://purl.uniprot.org/citations/20937701 | http://purl.uniprot.org/core/pages | "367-381"xsd:string |
| http://purl.uniprot.org/citations/20937701 | http://purl.uniprot.org/core/title | "Family-wide characterization of the DENN domain Rab GDP-GTP exchange factors."xsd:string |
| http://purl.uniprot.org/citations/20937701 | http://purl.uniprot.org/core/title | "Family-wide characterization of the DENN domain Rab GDP-GTP exchange factors."xsd:string |
| http://purl.uniprot.org/citations/20937701 | http://purl.uniprot.org/core/volume | "191"xsd:string |
| http://purl.uniprot.org/citations/20937701 | http://purl.uniprot.org/core/volume | "191"xsd:string |