| http://purl.uniprot.org/citations/20937871 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20937871 | http://www.w3.org/2000/01/rdf-schema#comment | "IL-33, a member of the IL-1-related cytokines, is considered to be a proallergic cytokine that is especially involved in Th2-type immune responses. Moreover, like IL-1α, IL-33 has been suggested to act as an "alarmin" that amplifies immune responses during tissue injury. In contrast to IL-1, however, the precise roles of IL-33 in those settings are poorly understood. Using IL-1- and IL-33-deficient mice, we found that IL-1, but not IL-33, played a substantial role in induction of T cell-mediated type IV hypersensitivity such as contact and delayed-type hypersensitivity and autoimmune diseases such as experimental autoimmune encephalomyelitis. Most notably, however, IL-33 was important for innate-type mucosal immunity in the lungs and gut. That is, IL-33 was essential for manifestation of T cell-independent protease allergen-induced airway inflammation as well as OVA-induced allergic topical airway inflammation, without affecting acquisition of antigen-specific memory T cells. IL-33 was significantly involved in the development of dextran-induced colitis accompanied by T cell-independent epithelial cell damage, but not in streptozocin-induced diabetes or Con A-induced hepatitis characterized by T cell-mediated apoptotic tissue destruction. In addition, IL-33-deficient mice showed a substantially diminished LPS-induced systemic inflammatory response. These observations indicate that IL-33 is a crucial amplifier of mucosal and systemic innate, rather than acquired, immune responses."xsd:string |
| http://purl.uniprot.org/citations/20937871 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.1003059107"xsd:string |
| http://purl.uniprot.org/citations/20937871 | http://purl.uniprot.org/core/author | "Abe T."xsd:string |
| http://purl.uniprot.org/citations/20937871 | http://purl.uniprot.org/core/author | "Morita H."xsd:string |
| http://purl.uniprot.org/citations/20937871 | http://purl.uniprot.org/core/author | "Matsumoto K."xsd:string |
| http://purl.uniprot.org/citations/20937871 | http://purl.uniprot.org/core/author | "Ohno T."xsd:string |
| http://purl.uniprot.org/citations/20937871 | http://purl.uniprot.org/core/author | "Okumura K."xsd:string |
| http://purl.uniprot.org/citations/20937871 | http://purl.uniprot.org/core/author | "Saito H."xsd:string |
| http://purl.uniprot.org/citations/20937871 | http://purl.uniprot.org/core/author | "Ishii A."xsd:string |
| http://purl.uniprot.org/citations/20937871 | http://purl.uniprot.org/core/author | "Sudo K."xsd:string |
| http://purl.uniprot.org/citations/20937871 | http://purl.uniprot.org/core/author | "Kiyonari H."xsd:string |
| http://purl.uniprot.org/citations/20937871 | http://purl.uniprot.org/core/author | "Nakae S."xsd:string |
| http://purl.uniprot.org/citations/20937871 | http://purl.uniprot.org/core/author | "Nambu A."xsd:string |
| http://purl.uniprot.org/citations/20937871 | http://purl.uniprot.org/core/author | "Kajiwara N."xsd:string |
| http://purl.uniprot.org/citations/20937871 | http://purl.uniprot.org/core/author | "Arae K."xsd:string |
| http://purl.uniprot.org/citations/20937871 | http://purl.uniprot.org/core/author | "Oboki K."xsd:string |
| http://purl.uniprot.org/citations/20937871 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20937871 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/20937871 | http://purl.uniprot.org/core/pages | "18581-18586"xsd:string |
| http://purl.uniprot.org/citations/20937871 | http://purl.uniprot.org/core/title | "IL-33 is a crucial amplifier of innate rather than acquired immunity."xsd:string |
| http://purl.uniprot.org/citations/20937871 | http://purl.uniprot.org/core/volume | "107"xsd:string |
| http://purl.uniprot.org/citations/20937871 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20937871 |
| http://purl.uniprot.org/citations/20937871 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20937871 |
| http://purl.uniprot.org/uniprot/#_D3Z6T7-mappedCitation-20937871 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20937871 |