| http://purl.uniprot.org/citations/20940704 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20940704 | http://www.w3.org/2000/01/rdf-schema#comment | "Protein kinases are organized in hierarchical networks that are assembled and regulated by scaffold proteins. Here, we identify the evolutionary conserved WD40-repeat protein Han11 as an interactor of the kinase homeodomain-interacting protein kinase 2 (HIPK2). In vitro experiments showed the direct binding of Han11 to HIPK2, but also to the kinases DYRK1a, DYRK1b and mitogen-activated protein kinase kinase kinase 1 (MEKK1). Han11 was required to allow coupling of MEKK1 to DYRK1 and HIPK2. Knockdown experiments in Caenorhabditis elegans showed the relevance of the Han11 orthologs Swan-1 and Swan-2 for the osmotic stress response. Downregulation of Han11 in human cells lowered the threshold and amplitude of HIPK2- and MEKK1-triggered signalling events and changed the kinetics of kinase induction. Han11 knockdown changed the amplitude and time dependence of HIPK2-driven transcription in response to DNA damage and also interfered with MEKK1-triggered gene expression and stress signalling. Impaired signal transmission also occurred upon interference with stoichiometrically assembled signalling complexes by Han11 overexpression. Collectively, these experiments identify Han11 as a novel scaffold protein regulating kinase signalling by HIPK2 and MEKK1."xsd:string |
| http://purl.uniprot.org/citations/20940704 | http://purl.org/dc/terms/identifier | "doi:10.1038/emboj.2010.251"xsd:string |
| http://purl.uniprot.org/citations/20940704 | http://purl.uniprot.org/core/author | "Lochnit G."xsd:string |
| http://purl.uniprot.org/citations/20940704 | http://purl.uniprot.org/core/author | "Grabitzki J."xsd:string |
| http://purl.uniprot.org/citations/20940704 | http://purl.uniprot.org/core/author | "Schmitz M.L."xsd:string |
| http://purl.uniprot.org/citations/20940704 | http://purl.uniprot.org/core/author | "Skurat A.V."xsd:string |
| http://purl.uniprot.org/citations/20940704 | http://purl.uniprot.org/core/author | "Ritterhoff S."xsd:string |
| http://purl.uniprot.org/citations/20940704 | http://purl.uniprot.org/core/author | "Farah C.M."xsd:string |
| http://purl.uniprot.org/citations/20940704 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20940704 | http://purl.uniprot.org/core/name | "EMBO J"xsd:string |
| http://purl.uniprot.org/citations/20940704 | http://purl.uniprot.org/core/pages | "3750-3761"xsd:string |
| http://purl.uniprot.org/citations/20940704 | http://purl.uniprot.org/core/title | "The WD40-repeat protein Han11 functions as a scaffold protein to control HIPK2 and MEKK1 kinase functions."xsd:string |
| http://purl.uniprot.org/citations/20940704 | http://purl.uniprot.org/core/volume | "29"xsd:string |
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