| http://purl.uniprot.org/citations/20945348 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20945348 | http://www.w3.org/2000/01/rdf-schema#comment | "The latent TGF-β binding proteins (LTBP-1 -3, and -4) assist in the secretion and localization of latent TGF-β molecules. Ltbp3(-/-) and Ltbp4S(-/-) mice have distinct phenotypes and only in the lungs does deficiency of either Ltbp-3 or Ltbp-4 cause developmental abnormalities. To determine if these two LTBPs have additional common functions, we generated mice deficient for both Ltbp-3 and Ltbp-4S. The only novel defect in Ltbp3(-/-);Ltbp4S(-/-) mice was an early lethality compared to mice with single mutations. In addition lung abnormalities were exacerbated and the terminal air sac septation defect was more severe in Ltbp3(-/-);Ltbp4S(-/-) mice than in Ltbp4S(-/-) mice. Decreased cellularity of Ltbp3(-/-);Ltbp4S(-/-) lungs was correlated with higher rate of apoptosis in newborn lungs of Ltbp3(-/-);Ltbp4S(-/-) animals compared to WT, Ltbp3(-/-), and Ltbp4S(-/-) mice. No differences in the maturation of the major lung cell types were discerned between the single and double mutant mice. However, the distribution of type 2 cells and myofibroblasts was abnormal, and myofibroblast segregation in some areas might be an indication of early fibrosis. We also observed differences in ECM composition between Ltbp3(-/-);Ltbp4S(-/-) and Ltbp4S(-/-) lungs after birth, reflected in decreased incorporation of fibrillin-1 and -2 in Ltbp3(-/-);Ltbp4S(-/-) matrix. The function of the lungs of Ltbp3(-/-);Ltbp4S(-/-) mice after the first week of life was potentially further compromised by macrophage infiltration, as proteases secreted from macrophages might exacerbate developmental emphysema. Together these data indicate that LTBP-3 and -4 perform partially overlapping functions only in the lungs."xsd:string |
| http://purl.uniprot.org/citations/20945348 | http://purl.org/dc/terms/identifier | "doi:10.1002/jcp.22479"xsd:string |
| http://purl.uniprot.org/citations/20945348 | http://purl.uniprot.org/core/author | "Singh A."xsd:string |
| http://purl.uniprot.org/citations/20945348 | http://purl.uniprot.org/core/author | "Chen Y."xsd:string |
| http://purl.uniprot.org/citations/20945348 | http://purl.uniprot.org/core/author | "Choi J."xsd:string |
| http://purl.uniprot.org/citations/20945348 | http://purl.uniprot.org/core/author | "Dabovic B."xsd:string |
| http://purl.uniprot.org/citations/20945348 | http://purl.uniprot.org/core/author | "Sakai L.Y."xsd:string |
| http://purl.uniprot.org/citations/20945348 | http://purl.uniprot.org/core/author | "Davis E.C."xsd:string |
| http://purl.uniprot.org/citations/20945348 | http://purl.uniprot.org/core/author | "Rifkin D.B."xsd:string |
| http://purl.uniprot.org/citations/20945348 | http://purl.uniprot.org/core/author | "Zilberberg L."xsd:string |
| http://purl.uniprot.org/citations/20945348 | http://purl.uniprot.org/core/author | "Todorovic V."xsd:string |
| http://purl.uniprot.org/citations/20945348 | http://purl.uniprot.org/core/author | "Vassallo M."xsd:string |
| http://purl.uniprot.org/citations/20945348 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/20945348 | http://purl.uniprot.org/core/name | "J Cell Physiol"xsd:string |
| http://purl.uniprot.org/citations/20945348 | http://purl.uniprot.org/core/pages | "1499-1509"xsd:string |
| http://purl.uniprot.org/citations/20945348 | http://purl.uniprot.org/core/title | "Control of lung development by latent TGF-beta binding proteins."xsd:string |
| http://purl.uniprot.org/citations/20945348 | http://purl.uniprot.org/core/volume | "226"xsd:string |
| http://purl.uniprot.org/citations/20945348 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20945348 |
| http://purl.uniprot.org/citations/20945348 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20945348 |
| http://purl.uniprot.org/uniprot/#_B2RU79-mappedCitation-20945348 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20945348 |
| http://purl.uniprot.org/uniprot/#_Q8BXY5-mappedCitation-20945348 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20945348 |
| http://purl.uniprot.org/uniprot/#_Q6KAT1-mappedCitation-20945348 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20945348 |
| http://purl.uniprot.org/uniprot/#_Q3UGU1-mappedCitation-20945348 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20945348 |
| http://purl.uniprot.org/uniprot/#_Q9CVK2-mappedCitation-20945348 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20945348 |