| http://purl.uniprot.org/citations/20946870 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20946870 | http://www.w3.org/2000/01/rdf-schema#comment | "Aminopeptidase A (APA; EC 3.4.11.7) is a transmembrane metalloprotease with several functions in tumor angiogenesis. To investigate the role of APA in the process of ischemia-induced angiogenesis, we evaluated the cellular angiogenic responses under hypoxic conditions and the process of perfusion recovery in the hindlimb ischemia model of APA-deficient (APA-KO; C57Bl6/J strain) mice. Western blotting of endothelial cells (ECs) isolated from the aorta of APA-KO mice revealed that the accumulation of hypoxia-inducible factor-1α (HIF-1α) protein in response to hypoxic challenge was blunted. Regarding the proteasomal ubiquitination, a proteasome inhibitor MG-132 restored the reduced accumulation of HIF-1α in ECs from APA-KO mice similar to control mice under hypoxic conditions. These were associated with decreased growth factor secretion and capillary formation in APA-KO mice. In the hindlimb ischemia model, perfusion recovery in APA-KO mice was decreased in accordance with a significantly lower capillary density at 2weeks. Regarding vasculogenesis, no differences were observed in cell populations and distribution patterns between wild type and APA-KO mice in relation to endothelial progenitor cells. Our results suggested that Ischemia-induced angiogenesis is impaired in APA-KO mice partly through decreased HIF-1α stability by proteasomal degradation and subsequent suppression of HIF-1α-driven target protein expression such as growth factors. APA is a functional target for ischemia-induced angiogenesis."xsd:string |
| http://purl.uniprot.org/citations/20946870 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2010.10.043"xsd:string |
| http://purl.uniprot.org/citations/20946870 | http://purl.uniprot.org/core/author | "Okumura K."xsd:string |
| http://purl.uniprot.org/citations/20946870 | http://purl.uniprot.org/core/author | "Niwa M."xsd:string |
| http://purl.uniprot.org/citations/20946870 | http://purl.uniprot.org/core/author | "Murohara T."xsd:string |
| http://purl.uniprot.org/citations/20946870 | http://purl.uniprot.org/core/author | "Ishii M."xsd:string |
| http://purl.uniprot.org/citations/20946870 | http://purl.uniprot.org/core/author | "Naruse K."xsd:string |
| http://purl.uniprot.org/citations/20946870 | http://purl.uniprot.org/core/author | "Kubota R."xsd:string |
| http://purl.uniprot.org/citations/20946870 | http://purl.uniprot.org/core/author | "Numaguchi Y."xsd:string |
| http://purl.uniprot.org/citations/20946870 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20946870 | http://purl.uniprot.org/core/name | "Biochem Biophys Res Commun"xsd:string |
| http://purl.uniprot.org/citations/20946870 | http://purl.uniprot.org/core/pages | "396-401"xsd:string |
| http://purl.uniprot.org/citations/20946870 | http://purl.uniprot.org/core/title | "Ischemia-induced angiogenesis is impaired in aminopeptidase A deficient mice via down-regulation of HIF-1alpha."xsd:string |
| http://purl.uniprot.org/citations/20946870 | http://purl.uniprot.org/core/volume | "402"xsd:string |
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