| http://purl.uniprot.org/citations/20947496 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20947496 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20947496 | http://www.w3.org/2000/01/rdf-schema#comment | "The identity of the putative G-protein coupled receptor (GPCR) that mediates the non-genomic effects of androgens is unknown. We present in vitro and in vivo evidence that the orphan GPRC6A receptor, a widely expressed calcium and amino acid sensing GPCR, transduces the non-genomic effects of testosterone and other steroids. Overexpression of GPRC6A imparts the ability of extracellular testosterone to illicit a rapid, non-genomic signaling response in HEK-293 cells lacking the androgen receptor. Conversely, testosterone-stimulated rapid signaling and phosphorylation of ERK is attenuated in bone marrow stromal cells derived from GPRC6A(-/-) mice and in 22Rv1 prostate cancer cells after siRNA-mediated knockdown of GPRC6A. Compared with wild-type controls, GPRC6A(-/-) null mice exhibit significantly less ERK activation and Egr-1 expression in both bone marrow and testis in response to pharmacological doses of testosterone in vivo. In addition, testosterone administration results in suppression of luteinizing hormone in wild-type male mice, but paradoxically stimulates serum luteinizing hormone levels in GPRC6A(-/-) null mice. These results suggest that GPRC6A is functionally important in regulating non-genomic effects of androgens in multiple tissues."xsd:string |
| http://purl.uniprot.org/citations/20947496 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m110.158063"xsd:string |
| http://purl.uniprot.org/citations/20947496 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m110.158063"xsd:string |
| http://purl.uniprot.org/citations/20947496 | http://purl.uniprot.org/core/author | "Pi M."xsd:string |
| http://purl.uniprot.org/citations/20947496 | http://purl.uniprot.org/core/author | "Pi M."xsd:string |
| http://purl.uniprot.org/citations/20947496 | http://purl.uniprot.org/core/author | "Quarles L.D."xsd:string |
| http://purl.uniprot.org/citations/20947496 | http://purl.uniprot.org/core/author | "Quarles L.D."xsd:string |
| http://purl.uniprot.org/citations/20947496 | http://purl.uniprot.org/core/author | "Parrill A.L."xsd:string |
| http://purl.uniprot.org/citations/20947496 | http://purl.uniprot.org/core/author | "Parrill A.L."xsd:string |
| http://purl.uniprot.org/citations/20947496 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20947496 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20947496 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/20947496 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/20947496 | http://purl.uniprot.org/core/pages | "39953-39964"xsd:string |
| http://purl.uniprot.org/citations/20947496 | http://purl.uniprot.org/core/pages | "39953-39964"xsd:string |
| http://purl.uniprot.org/citations/20947496 | http://purl.uniprot.org/core/title | "GPRC6A mediates the non-genomic effects of steroids."xsd:string |
| http://purl.uniprot.org/citations/20947496 | http://purl.uniprot.org/core/title | "GPRC6A mediates the non-genomic effects of steroids."xsd:string |
| http://purl.uniprot.org/citations/20947496 | http://purl.uniprot.org/core/volume | "285"xsd:string |
| http://purl.uniprot.org/citations/20947496 | http://purl.uniprot.org/core/volume | "285"xsd:string |
| http://purl.uniprot.org/citations/20947496 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20947496 |
| http://purl.uniprot.org/citations/20947496 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20947496 |
| http://purl.uniprot.org/citations/20947496 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20947496 |
| http://purl.uniprot.org/citations/20947496 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20947496 |