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http://purl.uniprot.org/citations/20948998http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/20948998http://www.w3.org/2000/01/rdf-schema#comment"

Background

Association of genetic-variants in the FADS1-FADS2-gene-cluster with fatty-acid-composition in blood of adult-populations is well established. We analyze this genetic-association in two children-cohort-studies. In addition, the association between variants in the FADS-gene-cluster and blood-fatty-acid-composition with eczema was studied.

Methods and principal findings

Data of two population-based-birth-cohorts in The Netherlands and Germany (KOALA, LISA) were pooled (nā€Š=ā€Š879) and analyzed by (logistic) regression regarding the mutual influence of single-nucleotide-polymorphisms (SNPs) in the FADS-gene-cluster (rs174545, rs174546, rs174556, rs174561, rs3834458), on polyunsaturated fatty acids (PUFA) in blood and parent-reported eczema until the age of 2 years. All SNPs were highly significantly associated with all PUFAs except for alpha-linolenic-acid and eicosapentaenoic-acid, also after correction for multiple-testing. All tested SNPs showed associations with eczema in the LISA-study, but not in the KOALA-study. None of the PUFAs was significantly associated with eczema neither in the pooled nor in the analyses stratified by study-cohort.

Conclusions and significance

PUFA-composition in young children's blood is under strong control of the FADS-gene-cluster. Inconsistent results were found for a link between these genetic-variants with eczema. PUFA in blood was not associated with eczema. Thus the hypothesis of an inflammatory-link between PUFA and eczema by the metabolic-pathway of LC-PUFAs as precursors for inflammatory prostaglandins and leukotrienes could not be confirmed by these data."xsd:string
http://purl.uniprot.org/citations/20948998http://purl.org/dc/terms/identifier"doi:10.1371/journal.pone.0013261"xsd:string
http://purl.uniprot.org/citations/20948998http://purl.uniprot.org/core/author"Koletzko B."xsd:string
http://purl.uniprot.org/citations/20948998http://purl.uniprot.org/core/author"Wichmann H.E."xsd:string
http://purl.uniprot.org/citations/20948998http://purl.uniprot.org/core/author"Postma D.S."xsd:string
http://purl.uniprot.org/citations/20948998http://purl.uniprot.org/core/author"Heinrich J."xsd:string
http://purl.uniprot.org/citations/20948998http://purl.uniprot.org/core/author"Schulz R."xsd:string
http://purl.uniprot.org/citations/20948998http://purl.uniprot.org/core/author"Herberth G."xsd:string
http://purl.uniprot.org/citations/20948998http://purl.uniprot.org/core/author"Emmrich F."xsd:string
http://purl.uniprot.org/citations/20948998http://purl.uniprot.org/core/author"Klopp N."xsd:string
http://purl.uniprot.org/citations/20948998http://purl.uniprot.org/core/author"Jansen E."xsd:string
http://purl.uniprot.org/citations/20948998http://purl.uniprot.org/core/author"Franke K."xsd:string
http://purl.uniprot.org/citations/20948998http://purl.uniprot.org/core/author"Koppelman G.H."xsd:string
http://purl.uniprot.org/citations/20948998http://purl.uniprot.org/core/author"Lehmann I."xsd:string
http://purl.uniprot.org/citations/20948998http://purl.uniprot.org/core/author"Glaser C."xsd:string
http://purl.uniprot.org/citations/20948998http://purl.uniprot.org/core/author"von Berg A."xsd:string
http://purl.uniprot.org/citations/20948998http://purl.uniprot.org/core/author"Borte M."xsd:string
http://purl.uniprot.org/citations/20948998http://purl.uniprot.org/core/author"Herbarth O."xsd:string
http://purl.uniprot.org/citations/20948998http://purl.uniprot.org/core/author"van den Brandt P.A."xsd:string
http://purl.uniprot.org/citations/20948998http://purl.uniprot.org/core/author"Dagnelie P.C."xsd:string
http://purl.uniprot.org/citations/20948998http://purl.uniprot.org/core/author"Schaaf B."xsd:string
http://purl.uniprot.org/citations/20948998http://purl.uniprot.org/core/author"Sack U."xsd:string
http://purl.uniprot.org/citations/20948998http://purl.uniprot.org/core/author"Thijs C."xsd:string
http://purl.uniprot.org/citations/20948998http://purl.uniprot.org/core/author"Rzehak P."xsd:string
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