| http://purl.uniprot.org/citations/20951345 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20951345 | http://www.w3.org/2000/01/rdf-schema#comment | "In the growth plate, the interplay between parathyroid hormone-related peptide (PTHrP) and Indian hedgehog (Ihh) signaling tightly regulates chondrocyte proliferation and differentiation during longitudinal bone growth. We found that PTHrP increases the expression of Zfp521, a zinc finger transcriptional coregulator, in prehypertrophic chondrocytes. Mice with chondrocyte-targeted deletion of Zfp521 resembled PTHrP(-/-) and chondrocyte-specific PTHR1(-/-) mice, with decreased chondrocyte proliferation, early hypertrophic transition, and reduced growth plate thickness. Deleting Zfp521 increased expression of Runx2 and Runx2 target genes, and decreased Cyclin D1 and Bcl-2 expression while increasing Caspase-3 activation and apoptosis. Zfp521 associated with Runx2 in chondrocytes, antagonizing its activity via an HDAC4-dependent mechanism. PTHrP failed to upregulate Cyclin D1 and to antagonize Runx2, Ihh, and collagen X expression when Zfp521 was absent. Thus, Zfp521 is an important PTHrP target gene that regulates growth plate chondrocyte proliferation and differentiation."xsd:string |
| http://purl.uniprot.org/citations/20951345 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.devcel.2010.09.008"xsd:string |
| http://purl.uniprot.org/citations/20951345 | http://purl.uniprot.org/core/author | "Maeda Y."xsd:string |
| http://purl.uniprot.org/citations/20951345 | http://purl.uniprot.org/core/author | "Saito H."xsd:string |
| http://purl.uniprot.org/citations/20951345 | http://purl.uniprot.org/core/author | "Copeland N.G."xsd:string |
| http://purl.uniprot.org/citations/20951345 | http://purl.uniprot.org/core/author | "Jenkins N.A."xsd:string |
| http://purl.uniprot.org/citations/20951345 | http://purl.uniprot.org/core/author | "Baron R."xsd:string |
| http://purl.uniprot.org/citations/20951345 | http://purl.uniprot.org/core/author | "Neff L."xsd:string |
| http://purl.uniprot.org/citations/20951345 | http://purl.uniprot.org/core/author | "Horne W.C."xsd:string |
| http://purl.uniprot.org/citations/20951345 | http://purl.uniprot.org/core/author | "Warming S."xsd:string |
| http://purl.uniprot.org/citations/20951345 | http://purl.uniprot.org/core/author | "Kiviranta R."xsd:string |
| http://purl.uniprot.org/citations/20951345 | http://purl.uniprot.org/core/author | "Lanske B."xsd:string |
| http://purl.uniprot.org/citations/20951345 | http://purl.uniprot.org/core/author | "Atfi A."xsd:string |
| http://purl.uniprot.org/citations/20951345 | http://purl.uniprot.org/core/author | "Hesse E."xsd:string |
| http://purl.uniprot.org/citations/20951345 | http://purl.uniprot.org/core/author | "Yamana K."xsd:string |
| http://purl.uniprot.org/citations/20951345 | http://purl.uniprot.org/core/author | "Sitara D."xsd:string |
| http://purl.uniprot.org/citations/20951345 | http://purl.uniprot.org/core/author | "Correa D."xsd:string |
| http://purl.uniprot.org/citations/20951345 | http://purl.uniprot.org/core/author | "Seriwatanachai D."xsd:string |
| http://purl.uniprot.org/citations/20951345 | http://purl.uniprot.org/core/author | "Coillard L."xsd:string |
| http://purl.uniprot.org/citations/20951345 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20951345 | http://purl.uniprot.org/core/name | "Dev Cell"xsd:string |
| http://purl.uniprot.org/citations/20951345 | http://purl.uniprot.org/core/pages | "533-546"xsd:string |
| http://purl.uniprot.org/citations/20951345 | http://purl.uniprot.org/core/title | "Zfp521 is a target gene and key effector of parathyroid hormone-related peptide signaling in growth plate chondrocytes."xsd:string |
| http://purl.uniprot.org/citations/20951345 | http://purl.uniprot.org/core/volume | "19"xsd:string |