| http://purl.uniprot.org/citations/20951947 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20951947 | http://www.w3.org/2000/01/rdf-schema#comment | "Microtubule inhibitors are important cancer drugs that induce mitotic arrest by activating the spindle assembly checkpoint (SAC), which, in turn, inhibits the ubiquitin ligase activity of the anaphase-promoting complex (APC). Here, we report a small molecule, tosyl-L-arginine methyl ester (TAME), which binds to the APC and prevents its activation by Cdc20 and Cdh1. A prodrug of TAME arrests cells in metaphase without perturbing the spindle, but nonetheless the arrest is dependent on the SAC. Metaphase arrest induced by a proteasome inhibitor is also SAC dependent, suggesting that APC-dependent proteolysis is required to inactivate the SAC. We propose that mutual antagonism between the APC and the SAC yields a positive feedback loop that amplifies the ability of TAME to induce mitotic arrest."xsd:string |
| http://purl.uniprot.org/citations/20951947 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.ccr.2010.08.010"xsd:string |
| http://purl.uniprot.org/citations/20951947 | http://purl.uniprot.org/core/author | "Choi S."xsd:string |
| http://purl.uniprot.org/citations/20951947 | http://purl.uniprot.org/core/author | "Zeng X."xsd:string |
| http://purl.uniprot.org/citations/20951947 | http://purl.uniprot.org/core/author | "Cuny G.D."xsd:string |
| http://purl.uniprot.org/citations/20951947 | http://purl.uniprot.org/core/author | "Oh D.C."xsd:string |
| http://purl.uniprot.org/citations/20951947 | http://purl.uniprot.org/core/author | "King R.W."xsd:string |
| http://purl.uniprot.org/citations/20951947 | http://purl.uniprot.org/core/author | "Sigoillot F."xsd:string |
| http://purl.uniprot.org/citations/20951947 | http://purl.uniprot.org/core/author | "Gaur S."xsd:string |
| http://purl.uniprot.org/citations/20951947 | http://purl.uniprot.org/core/author | "Dimova N."xsd:string |
| http://purl.uniprot.org/citations/20951947 | http://purl.uniprot.org/core/author | "Pfaff K.L."xsd:string |
| http://purl.uniprot.org/citations/20951947 | http://purl.uniprot.org/core/author | "Hathaway N."xsd:string |
| http://purl.uniprot.org/citations/20951947 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20951947 | http://purl.uniprot.org/core/name | "Cancer Cell"xsd:string |
| http://purl.uniprot.org/citations/20951947 | http://purl.uniprot.org/core/pages | "382-395"xsd:string |
| http://purl.uniprot.org/citations/20951947 | http://purl.uniprot.org/core/title | "Pharmacologic inhibition of the anaphase-promoting complex induces a spindle checkpoint-dependent mitotic arrest in the absence of spindle damage."xsd:string |
| http://purl.uniprot.org/citations/20951947 | http://purl.uniprot.org/core/volume | "18"xsd:string |
| http://purl.uniprot.org/citations/20951947 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20951947 |
| http://purl.uniprot.org/citations/20951947 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20951947 |
| http://purl.uniprot.org/uniprot/#_C6ZIW0-mappedCitation-20951947 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20951947 |
| http://purl.uniprot.org/uniprot/#_Q12834-mappedCitation-20951947 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20951947 |
| http://purl.uniprot.org/uniprot/#_Q13257-mappedCitation-20951947 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20951947 |
| http://purl.uniprot.org/uniprot/#_O60566-mappedCitation-20951947 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20951947 |
| http://purl.uniprot.org/uniprot/#_P12830-mappedCitation-20951947 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20951947 |