| http://purl.uniprot.org/citations/20952511 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20952511 | http://www.w3.org/2000/01/rdf-schema#comment | "Chronic myelogenous leukemia (CML) is characterized by the expression of BCR-ABL tyrosine kinase, which results in increased cell proliferation and inhibition of apoptosis. In this study, we show that BCR-ABL-positive CML cell lines treated with imatinib (STI571) undergo G₁ cell cycle arrest associated with the accumulation of p57(Kip)², a cyclin-dependent kinase inhibitor (CKI). Interestingly, p57(Kip)² increase precedes the reported STI571-dependent upregulation of p27(Kip)¹. A number of complementary approaches allow the demonstration that p57(Kip)² buildup is due to the transcriptional activation of CDKN1C, the p57(Kip)²-encoding gene, while neither p57(Kip)² half-life elongation nor its cell relocalization were observed. We also identified a heretofore undescribed pattern of p57(Kip)² phosphorylated isoforms which, however, did not change in response to STI571 cell treatment. The imatinib-dependent p57(Kip)² upregulation occurs only in STI571-responsive cells, while the CKI accumulation was not evidenced in an imatinib-resistant clone. Nilotinib and dasatinib (second-generation BCR-ABL inhibitors), at concentrations comparable to those used in therapy, increase the CKI but do not affect p27(Kip)¹ level. Finally, CD34(+) cells from CML patients display a clear imatinib-dependent p57(Kip)² upregulation, which was not observed in CD34(+) cells from control subjects. In conclusion, our study points to p57(Kip)² as a novel and precocious effector of BCR-ABL targeting drugs."xsd:string |
| http://purl.uniprot.org/citations/20952511 | http://purl.org/dc/terms/identifier | "doi:10.1093/carcin/bgq211"xsd:string |
| http://purl.uniprot.org/citations/20952511 | http://purl.uniprot.org/core/author | "Perrotta S."xsd:string |
| http://purl.uniprot.org/citations/20952511 | http://purl.uniprot.org/core/author | "Oliva A."xsd:string |
| http://purl.uniprot.org/citations/20952511 | http://purl.uniprot.org/core/author | "Della Ragione F."xsd:string |
| http://purl.uniprot.org/citations/20952511 | http://purl.uniprot.org/core/author | "Borriello A."xsd:string |
| http://purl.uniprot.org/citations/20952511 | http://purl.uniprot.org/core/author | "Cucciolla V."xsd:string |
| http://purl.uniprot.org/citations/20952511 | http://purl.uniprot.org/core/author | "Bencivenga D."xsd:string |
| http://purl.uniprot.org/citations/20952511 | http://purl.uniprot.org/core/author | "Caldarelli I."xsd:string |
| http://purl.uniprot.org/citations/20952511 | http://purl.uniprot.org/core/author | "Danise P."xsd:string |
| http://purl.uniprot.org/citations/20952511 | http://purl.uniprot.org/core/author | "Usala E."xsd:string |
| http://purl.uniprot.org/citations/20952511 | http://purl.uniprot.org/core/author | "Ronzoni L."xsd:string |
| http://purl.uniprot.org/citations/20952511 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/20952511 | http://purl.uniprot.org/core/name | "Carcinogenesis"xsd:string |
| http://purl.uniprot.org/citations/20952511 | http://purl.uniprot.org/core/pages | "10-18"xsd:string |
| http://purl.uniprot.org/citations/20952511 | http://purl.uniprot.org/core/title | "p57Kip2 is a downstream effector of BCR-ABL kinase inhibitors in chronic myelogenous leukemia cells."xsd:string |
| http://purl.uniprot.org/citations/20952511 | http://purl.uniprot.org/core/volume | "32"xsd:string |
| http://purl.uniprot.org/citations/20952511 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20952511 |
| http://purl.uniprot.org/citations/20952511 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20952511 |
| http://purl.uniprot.org/uniprot/#_P38936-mappedCitation-20952511 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20952511 |
| http://purl.uniprot.org/uniprot/#_P49918-mappedCitation-20952511 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20952511 |
| http://purl.uniprot.org/uniprot/#_P00519-mappedCitation-20952511 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20952511 |
| http://purl.uniprot.org/uniprot/#_Q13882-mappedCitation-20952511 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20952511 |
| http://purl.uniprot.org/uniprot/#_P24385-mappedCitation-20952511 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20952511 |