| http://purl.uniprot.org/citations/20955788 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20955788 | http://www.w3.org/2000/01/rdf-schema#comment | "The facile abstraction of bis-allylic hydrogens from polyunsaturated fatty acids (PUFAs) is the hallmark chemistry responsible for initiation and propagation of autoxidation reactions. The products of these autoxidation reactions can form cross-links to other membrane components and damage proteins and nucleic acids. We report that PUFAs deuterated at bis-allylic sites are much more resistant to autoxidation reactions, because of the isotope effect. This is shown using coenzyme Q-deficient Saccharomyces cerevisiae coq mutants with defects in the biosynthesis of coenzyme Q (Q). Q functions in respiratory energy metabolism and also functions as a lipid-soluble antioxidant. Yeast coq mutants incubated in the presence of the PUFA α-linolenic or linoleic acid exhibit 99% loss of colony formation after 4h, demonstrating a profound loss of viability. In contrast, coq mutants treated with monounsaturated oleic acid or with one of the deuterated PUFAs, 11,11-D(2)-linoleic or 11,11,14,14-D(4)-α-linolenic acid, retain viability similar to wild-type yeast. Deuterated PUFAs also confer protection to wild-type yeast subjected to heat stress. These results indicate that isotope-reinforced PUFAs are stabilized compared to standard PUFAs, and they protect coq mutants and wild-type yeast cells against the toxic effects of lipid autoxidation products. These findings suggest new approaches to controlling ROS-inflicted cellular damage and oxidative stress."xsd:string |
| http://purl.uniprot.org/citations/20955788 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.freeradbiomed.2010.10.690"xsd:string |
| http://purl.uniprot.org/citations/20955788 | http://purl.uniprot.org/core/author | "Hill S."xsd:string |
| http://purl.uniprot.org/citations/20955788 | http://purl.uniprot.org/core/author | "Hirano K."xsd:string |
| http://purl.uniprot.org/citations/20955788 | http://purl.uniprot.org/core/author | "Clarke C.F."xsd:string |
| http://purl.uniprot.org/citations/20955788 | http://purl.uniprot.org/core/author | "Marbois B.N."xsd:string |
| http://purl.uniprot.org/citations/20955788 | http://purl.uniprot.org/core/author | "Vidovic D."xsd:string |
| http://purl.uniprot.org/citations/20955788 | http://purl.uniprot.org/core/author | "Fine J."xsd:string |
| http://purl.uniprot.org/citations/20955788 | http://purl.uniprot.org/core/author | "Kay B."xsd:string |
| http://purl.uniprot.org/citations/20955788 | http://purl.uniprot.org/core/author | "Tse V."xsd:string |
| http://purl.uniprot.org/citations/20955788 | http://purl.uniprot.org/core/author | "Bekish A.V."xsd:string |
| http://purl.uniprot.org/citations/20955788 | http://purl.uniprot.org/core/author | "Shchepinov M.S."xsd:string |
| http://purl.uniprot.org/citations/20955788 | http://purl.uniprot.org/core/author | "Shmanai V.V."xsd:string |
| http://purl.uniprot.org/citations/20955788 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/20955788 | http://purl.uniprot.org/core/name | "Free Radic Biol Med"xsd:string |
| http://purl.uniprot.org/citations/20955788 | http://purl.uniprot.org/core/pages | "130-138"xsd:string |
| http://purl.uniprot.org/citations/20955788 | http://purl.uniprot.org/core/title | "Isotope-reinforced polyunsaturated fatty acids protect yeast cells from oxidative stress."xsd:string |
| http://purl.uniprot.org/citations/20955788 | http://purl.uniprot.org/core/volume | "50"xsd:string |
| http://purl.uniprot.org/citations/20955788 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20955788 |
| http://purl.uniprot.org/citations/20955788 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20955788 |
| http://purl.uniprot.org/uniprot/#_P41735-mappedCitation-20955788 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20955788 |
| http://purl.uniprot.org/uniprot/#_P00830-mappedCitation-20955788 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20955788 |
| http://purl.uniprot.org/uniprot/#_Q05779-mappedCitation-20955788 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20955788 |
| http://purl.uniprot.org/uniprot/#_P27680-mappedCitation-20955788 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20955788 |