| http://purl.uniprot.org/citations/20956541 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20956541 | http://www.w3.org/2000/01/rdf-schema#comment | "Acid sphingomyelinase (A-SMase) is an important enzyme in sphingolipid metabolism and plays key roles in apoptosis, immunity, development, and cancer. In addition, it mediates cytotoxicity of cisplatin and some other chemotherapeutic drugs. The mechanism of A-SMase activation is still undefined. We now demonstrate that, upon CD95 stimulation, A-SMase is activated through translocation from intracellular compartments to the plasma membrane in an exocytic pathway requiring the t-SNARE protein syntaxin 4. Indeed, down-regulation of syntaxin 4 inhibits A-SMase translocation and activation induced by CD95 stimulation. This leads to inhibition of the CD95-triggered signaling events, including caspase 3 and 9 activation and apoptosis, activation of the survival pathway involving the protein kinase Akt, and important changes in cell cycle and proliferation. The molecular interaction between A-SMase and syntaxin 4 was not known and clarifies the mechanism of A-SMase activation. The novel actions of syntaxin 4 in sphingolipid metabolism and exocytosis we describe here define signaling mechanisms of broad relevance in cell pathophysiology."xsd:string |
| http://purl.uniprot.org/citations/20956541 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m110.139287"xsd:string |
| http://purl.uniprot.org/citations/20956541 | http://purl.uniprot.org/core/author | "Rosa P."xsd:string |
| http://purl.uniprot.org/citations/20956541 | http://purl.uniprot.org/core/author | "Zhang Y."xsd:string |
| http://purl.uniprot.org/citations/20956541 | http://purl.uniprot.org/core/author | "Bassi M.T."xsd:string |
| http://purl.uniprot.org/citations/20956541 | http://purl.uniprot.org/core/author | "Gulbins E."xsd:string |
| http://purl.uniprot.org/citations/20956541 | http://purl.uniprot.org/core/author | "Perrotta C."xsd:string |
| http://purl.uniprot.org/citations/20956541 | http://purl.uniprot.org/core/author | "Simbari F."xsd:string |
| http://purl.uniprot.org/citations/20956541 | http://purl.uniprot.org/core/author | "Clementi E."xsd:string |
| http://purl.uniprot.org/citations/20956541 | http://purl.uniprot.org/core/author | "Morlacchi S."xsd:string |
| http://purl.uniprot.org/citations/20956541 | http://purl.uniprot.org/core/author | "Bizzozero L."xsd:string |
| http://purl.uniprot.org/citations/20956541 | http://purl.uniprot.org/core/author | "Assi E."xsd:string |
| http://purl.uniprot.org/citations/20956541 | http://purl.uniprot.org/core/author | "Cazzato D."xsd:string |
| http://purl.uniprot.org/citations/20956541 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20956541 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/20956541 | http://purl.uniprot.org/core/pages | "40240-40251"xsd:string |
| http://purl.uniprot.org/citations/20956541 | http://purl.uniprot.org/core/title | "Syntaxin 4 is required for acid sphingomyelinase activity and apoptotic function."xsd:string |
| http://purl.uniprot.org/citations/20956541 | http://purl.uniprot.org/core/volume | "285"xsd:string |
| http://purl.uniprot.org/citations/20956541 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20956541 |
| http://purl.uniprot.org/citations/20956541 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20956541 |
| http://purl.uniprot.org/uniprot/P17405#attribution-9851849ADB61F075738F88A84E3B7474 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/20956541 |
| http://purl.uniprot.org/uniprot/P11279#attribution-9851849ADB61F075738F88A84E3B7474 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/20956541 |
| http://purl.uniprot.org/uniprot/Q12846#attribution-45A3808D6322E19D253DBE0110D7271B | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/20956541 |
| http://purl.uniprot.org/uniprot/Q12846#attribution-9851849ADB61F075738F88A84E3B7474 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/20956541 |