| http://purl.uniprot.org/citations/20956979 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20956979 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20956979 | http://www.w3.org/2000/01/rdf-schema#comment | "Dysbindin-1 regulates D2-receptor trafficking and is implicated in schizophrenia and related cognitive abnormalities, but whether this molecular effect mediates the clinical manifestations of the disorder is unknown. We explored in dysbindin-1-deficient mice (dys-/-) (1) schizophrenia-related behaviors, (2) molecular and electrophysiological changes in medial prefrontal cortex (mPFC) and (3) the dependence of these on D2-receptor stimulation. Dysbindin-1 disruption altered dopamine-related behaviors and impaired working memory under challenging/stressful conditions. Dys-/-pyramidal neurons in mPFC layers II/III were hyperexcitable at baseline but hypoexcitable following D2 stimulation. Dys-/-were also respectively more and less sensitive to D2 agonist- and antagonist-induced behavioral effects. Dys-/-had reduced expression of Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) and CaMKKβ in mPFC. Chronic D2 agonist treatment reproduced these changes in protein expression, and some of the dys-/-behavioral effects. These results elucidate dysbindin's modulation of D2-related behavior, cortical activity and mPFC CaMK components, implicating cellular and molecular mechanisms of the association of dysbindin with psychosis."xsd:string |
| http://purl.uniprot.org/citations/20956979 | http://purl.org/dc/terms/identifier | "doi:10.1038/mp.2010.106"xsd:string |
| http://purl.uniprot.org/citations/20956979 | http://purl.org/dc/terms/identifier | "doi:10.1038/mp.2010.106"xsd:string |
| http://purl.uniprot.org/citations/20956979 | http://purl.uniprot.org/core/author | "Chen J."xsd:string |
| http://purl.uniprot.org/citations/20956979 | http://purl.uniprot.org/core/author | "Chen J."xsd:string |
| http://purl.uniprot.org/citations/20956979 | http://purl.uniprot.org/core/author | "Yang F."xsd:string |
| http://purl.uniprot.org/citations/20956979 | http://purl.uniprot.org/core/author | "Yang F."xsd:string |
| http://purl.uniprot.org/citations/20956979 | http://purl.uniprot.org/core/author | "Lu B."xsd:string |
| http://purl.uniprot.org/citations/20956979 | http://purl.uniprot.org/core/author | "Lu B."xsd:string |
| http://purl.uniprot.org/citations/20956979 | http://purl.uniprot.org/core/author | "Garcia S."xsd:string |
| http://purl.uniprot.org/citations/20956979 | http://purl.uniprot.org/core/author | "Garcia S."xsd:string |
| http://purl.uniprot.org/citations/20956979 | http://purl.uniprot.org/core/author | "Papaleo F."xsd:string |
| http://purl.uniprot.org/citations/20956979 | http://purl.uniprot.org/core/author | "Papaleo F."xsd:string |
| http://purl.uniprot.org/citations/20956979 | http://purl.uniprot.org/core/author | "Weinberger D.R."xsd:string |
| http://purl.uniprot.org/citations/20956979 | http://purl.uniprot.org/core/author | "Weinberger D.R."xsd:string |
| http://purl.uniprot.org/citations/20956979 | http://purl.uniprot.org/core/author | "Crawley J.N."xsd:string |
| http://purl.uniprot.org/citations/20956979 | http://purl.uniprot.org/core/author | "Crawley J.N."xsd:string |
| http://purl.uniprot.org/citations/20956979 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/20956979 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/20956979 | http://purl.uniprot.org/core/name | "Mol. Psychiatry"xsd:string |
| http://purl.uniprot.org/citations/20956979 | http://purl.uniprot.org/core/name | "Mol. Psychiatry"xsd:string |
| http://purl.uniprot.org/citations/20956979 | http://purl.uniprot.org/core/pages | "85-98"xsd:string |
| http://purl.uniprot.org/citations/20956979 | http://purl.uniprot.org/core/pages | "85-98"xsd:string |