| http://purl.uniprot.org/citations/20959455 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20959455 | http://www.w3.org/2000/01/rdf-schema#comment | "Head and neck squamous cell carcinoma cells exposed to cisplatin display ATM-dependent phosphorylation of the most predominant TP63 isoform (ΔNp63α), leading to its activation as a transcription factor. Here, we found that the phospho-ΔNp63α protein binds to the genomic promoter of RPN13 through the TP63-responsive element. We further found that the phospho-ΔNp63α protein associates with other transcription factors (DDIT3 (also known as CHOP), NF-Y, and NF-κB), activating RPN13 gene transcription. Furthermore, cisplatin-induced and phospho-ΔNp63α-dependent RPN13 gene transcription leads to NOS2 degradation. Finally, we show that RPN13 knockdown by siRNA essentially rescues NOS2 from cisplatin-dependent inactivation. These data provide a novel mechanism for the phospho-ΔNp63α-dependent regulation of NOS2 function in cells upon cisplatin treatment, contributing to the cell death pathway of tumor cells."xsd:string |
| http://purl.uniprot.org/citations/20959455 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m110.158642"xsd:string |
| http://purl.uniprot.org/citations/20959455 | http://purl.uniprot.org/core/author | "Huang Y."xsd:string |
| http://purl.uniprot.org/citations/20959455 | http://purl.uniprot.org/core/author | "Ratovitski E.A."xsd:string |
| http://purl.uniprot.org/citations/20959455 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20959455 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/20959455 | http://purl.uniprot.org/core/pages | "41422-41431"xsd:string |
| http://purl.uniprot.org/citations/20959455 | http://purl.uniprot.org/core/title | "Phosphorylated TP63 induces transcription of RPN13, leading to NOS2 protein degradation."xsd:string |
| http://purl.uniprot.org/citations/20959455 | http://purl.uniprot.org/core/volume | "285"xsd:string |
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