| http://purl.uniprot.org/citations/20966935 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20966935 | http://www.w3.org/2000/01/rdf-schema#comment | "B-cell lymphoma 6 (BCL6) and PR domain containing 1 (PRDM1) are considered as master regulators for germinal center (GC) formation and terminal B-cell differentiation. Dysregulation of BCL6 and PRDM1 has been associated with lymphomagenesis. Here, we show for the first time that direct cell-cell contact between follicular dendritic cells (FDC) and B-lymphocytes, by influencing the expression of a set of microRNAs (miRNAs), regulates the expression of BCL6 and PRDM1. We identify that, on cell adhesion to FDC, FDC induces upregulation of PRDM1 expression through downregulation of miR-9 and let-7 families and induces downregulation of BCL-6 through upregulation of miR-30 family in B-lymphocytes and lymphoma cells. We further demonstrate that the miR-30 family directly controls BCL-6 expression and miR-9-1 and let-7a directly control PRDM-1 expression through targeting their 3'UTR, mediating the FDC effect. Our studies define a novel regulatory mechanism in which the FDC, through induction of miRNAs in B-lymphocytes, orchestrates the regulation of transcription factors, promotes germinal center B-cell survival and differentiation. Dysregulation of miRNAs may interfere with B-cell survival and maturation, thus representing a novel molecular mechanism, as well as a potential therapeutic target in B-cell lymphomas."xsd:string |
| http://purl.uniprot.org/citations/20966935 | http://purl.org/dc/terms/identifier | "doi:10.1038/leu.2010.230"xsd:string |
| http://purl.uniprot.org/citations/20966935 | http://purl.uniprot.org/core/author | "Lin J."xsd:string |
| http://purl.uniprot.org/citations/20966935 | http://purl.uniprot.org/core/author | "Tao J."xsd:string |
| http://purl.uniprot.org/citations/20966935 | http://purl.uniprot.org/core/author | "Choi Y.S."xsd:string |
| http://purl.uniprot.org/citations/20966935 | http://purl.uniprot.org/core/author | "Zhao J.J."xsd:string |
| http://purl.uniprot.org/citations/20966935 | http://purl.uniprot.org/core/author | "Sotomayor E.M."xsd:string |
| http://purl.uniprot.org/citations/20966935 | http://purl.uniprot.org/core/author | "Tam W."xsd:string |
| http://purl.uniprot.org/citations/20966935 | http://purl.uniprot.org/core/author | "Moscinski L.C."xsd:string |
| http://purl.uniprot.org/citations/20966935 | http://purl.uniprot.org/core/author | "Wright K.L."xsd:string |
| http://purl.uniprot.org/citations/20966935 | http://purl.uniprot.org/core/author | "Dalton W.S."xsd:string |
| http://purl.uniprot.org/citations/20966935 | http://purl.uniprot.org/core/author | "Lwin T."xsd:string |
| http://purl.uniprot.org/citations/20966935 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/20966935 | http://purl.uniprot.org/core/name | "Leukemia"xsd:string |
| http://purl.uniprot.org/citations/20966935 | http://purl.uniprot.org/core/pages | "145-152"xsd:string |
| http://purl.uniprot.org/citations/20966935 | http://purl.uniprot.org/core/title | "Follicular dendritic cell-induced microRNA-mediated upregulation of PRDM1 and downregulation of BCL-6 in non-Hodgkin's B-cell lymphomas."xsd:string |
| http://purl.uniprot.org/citations/20966935 | http://purl.uniprot.org/core/volume | "25"xsd:string |
| http://purl.uniprot.org/citations/20966935 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20966935 |
| http://purl.uniprot.org/citations/20966935 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20966935 |
| http://purl.uniprot.org/uniprot/#_A1YZ20-mappedCitation-20966935 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20966935 |
| http://purl.uniprot.org/uniprot/#_A0A3B3IU23-mappedCitation-20966935 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20966935 |
| http://purl.uniprot.org/uniprot/#_A8K0J1-mappedCitation-20966935 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20966935 |
| http://purl.uniprot.org/uniprot/#_B4DW27-mappedCitation-20966935 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20966935 |
| http://purl.uniprot.org/uniprot/#_O75626-mappedCitation-20966935 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20966935 |