| http://purl.uniprot.org/citations/20971950 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20971950 | http://www.w3.org/2000/01/rdf-schema#comment | "The interleukin (IL)-22R1 chain of the heterodimeric IL-22 receptor is not expressed on normal leukocytes, but this receptor is expressed on T cells from anaplastic lymphoma kinase-positive (ALK(+)) anaplastic large cell lymphoma (ALCL) patients. To investigate the consequences of aberrant expression of this receptor on lymphocytes, we generated transgenic mice that express IL-22R1 on lymphocytes. The health of these animals progressively deteriorated at 8 to 12 weeks of age, as they displayed respiratory distress, rough coat and sluggish movement, and subsequent lethality due to multiorgan inflammation. The IL-22R1 transgenic animals developed neutrophilia that correlated with increased levels of circulating IL-17 and granulocyte colony-stimulating factor. In addition, these mice had increased serum IL-22 levels, suggesting that T cells expressing IL-22R1 generate IL-22 in a positive autoregulatory loop. As a result of the mouse model findings, we analyzed circulating cytokine levels in ALK(+)ALCL patients and detected elevated levels of IL-22, IL-17, and IL-8 in untreated patient samples. Importantly, IL-22 and IL-17 were undetectable in all patients who were in complete remission after chemotherapy. This study documents a previously unknown role of IL-22R1 in inflammation and identifies the involvement of IL-22R1/IL-22 in ALK(+)ALCL."xsd:string |
| http://purl.uniprot.org/citations/20971950 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood-2010-05-285908"xsd:string |
| http://purl.uniprot.org/citations/20971950 | http://purl.uniprot.org/core/author | "Wilson W.H."xsd:string |
| http://purl.uniprot.org/citations/20971950 | http://purl.uniprot.org/core/author | "Feigenbaum L."xsd:string |
| http://purl.uniprot.org/citations/20971950 | http://purl.uniprot.org/core/author | "Anderson S.K."xsd:string |
| http://purl.uniprot.org/citations/20971950 | http://purl.uniprot.org/core/author | "Pittaluga S."xsd:string |
| http://purl.uniprot.org/citations/20971950 | http://purl.uniprot.org/core/author | "Ramakrishnan K."xsd:string |
| http://purl.uniprot.org/citations/20971950 | http://purl.uniprot.org/core/author | "Young H.A."xsd:string |
| http://purl.uniprot.org/citations/20971950 | http://purl.uniprot.org/core/author | "Donnelly R.P."xsd:string |
| http://purl.uniprot.org/citations/20971950 | http://purl.uniprot.org/core/author | "Savan R."xsd:string |
| http://purl.uniprot.org/citations/20971950 | http://purl.uniprot.org/core/author | "Klinman D.M."xsd:string |
| http://purl.uniprot.org/citations/20971950 | http://purl.uniprot.org/core/author | "Shirota H."xsd:string |
| http://purl.uniprot.org/citations/20971950 | http://purl.uniprot.org/core/author | "Reynolds D.A."xsd:string |
| http://purl.uniprot.org/citations/20971950 | http://purl.uniprot.org/core/author | "Dunleavy K."xsd:string |
| http://purl.uniprot.org/citations/20971950 | http://purl.uniprot.org/core/author | "Karwan M."xsd:string |
| http://purl.uniprot.org/citations/20971950 | http://purl.uniprot.org/core/author | "McFarland A.P."xsd:string |
| http://purl.uniprot.org/citations/20971950 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/20971950 | http://purl.uniprot.org/core/name | "Blood"xsd:string |
| http://purl.uniprot.org/citations/20971950 | http://purl.uniprot.org/core/pages | "575-584"xsd:string |
| http://purl.uniprot.org/citations/20971950 | http://purl.uniprot.org/core/title | "A novel role for IL-22R1 as a driver of inflammation."xsd:string |
| http://purl.uniprot.org/citations/20971950 | http://purl.uniprot.org/core/volume | "117"xsd:string |
| http://purl.uniprot.org/citations/20971950 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20971950 |
| http://purl.uniprot.org/citations/20971950 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20971950 |
| http://purl.uniprot.org/uniprot/#_A0A0U1RP02-mappedCitation-20971950 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20971950 |