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| http://purl.uniprot.org/citations/20974136 | http://www.w3.org/2000/01/rdf-schema#comment | "We identified the Wilms' tumor protein, Wt1, as a novel transcriptional activator of the immunosuppressant cytokine interleukin-10 (IL-10). Silencing of Wt1 by RNA interference reduced IL-10 mRNA levels by approximately 90%. IL-10 transcripts were increased more than 15-fold upon forced expression of Wt1. Electrophoretic mobility shift assay and chromatin immunoprecipitation revealed a cis-element that was responsible for activation of the IL-10 promoter by Wt1 in murine macrophages. Mutation of the Wt1 binding motif abrogated stimulation of the IL-10 promoter by tumor necrosis factor-α (TNFα). These results suggest a novel immune regulatory function of Wt1 in controlling IL-10 gene expression."xsd:string |
| http://purl.uniprot.org/citations/20974136 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.febslet.2010.10.045"xsd:string |
| http://purl.uniprot.org/citations/20974136 | http://purl.uniprot.org/core/author | "Scholz H."xsd:string |
| http://purl.uniprot.org/citations/20974136 | http://purl.uniprot.org/core/author | "Kirschner K.M."xsd:string |
| http://purl.uniprot.org/citations/20974136 | http://purl.uniprot.org/core/author | "Sciesielski L.K."xsd:string |
| http://purl.uniprot.org/citations/20974136 | http://purl.uniprot.org/core/author | "Persson A.B."xsd:string |
| http://purl.uniprot.org/citations/20974136 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20974136 | http://purl.uniprot.org/core/name | "FEBS Lett"xsd:string |
| http://purl.uniprot.org/citations/20974136 | http://purl.uniprot.org/core/pages | "4665-4671"xsd:string |
| http://purl.uniprot.org/citations/20974136 | http://purl.uniprot.org/core/title | "Wilms' tumor protein Wt1 regulates the Interleukin-10 (IL-10) gene."xsd:string |
| http://purl.uniprot.org/citations/20974136 | http://purl.uniprot.org/core/volume | "584"xsd:string |
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