| http://purl.uniprot.org/citations/20974809 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20974809 | http://www.w3.org/2000/01/rdf-schema#comment | "cis-acting elements found in 3'-untranslated regions (UTRs) are regulatory signals determining mRNA stability and translational efficiency. By binding a novel non-AU-rich 69-nucleotide (nt) c-fms 3' UTR sequence, we previously identified HuR as a promoter of c-fms proto-oncogene mRNA. We now identify the 69-nt c-fms mRNA 3' UTR sequence as a cellular vigilin target through which vigilin inhibits the expression of c-fms mRNA and protein. Altering association of either vigilin or HuR with c-fms mRNA in vivo reciprocally affected mRNA association with the other protein. Mechanistic studies show that vigilin decreased c-fms mRNA stability. Furthermore, vigilin inhibited c-fms translation. Vigilin suppresses while HuR encourages cellular motility and invasion of breast cancer cells. In summary, we identified a competition for binding the 69-nt sequence, through which vigilin and HuR exert opposing effects on c-fms expression, suggesting a role for vigilin in suppression of breast cancer progression."xsd:string |
| http://purl.uniprot.org/citations/20974809 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.01031-10"xsd:string |
| http://purl.uniprot.org/citations/20974809 | http://purl.uniprot.org/core/author | "Baker T."xsd:string |
| http://purl.uniprot.org/citations/20974809 | http://purl.uniprot.org/core/author | "Yi X."xsd:string |
| http://purl.uniprot.org/citations/20974809 | http://purl.uniprot.org/core/author | "Woo H.H."xsd:string |
| http://purl.uniprot.org/citations/20974809 | http://purl.uniprot.org/core/author | "Lamb T."xsd:string |
| http://purl.uniprot.org/citations/20974809 | http://purl.uniprot.org/core/author | "Shapiro D.J."xsd:string |
| http://purl.uniprot.org/citations/20974809 | http://purl.uniprot.org/core/author | "Chambers S.K."xsd:string |
| http://purl.uniprot.org/citations/20974809 | http://purl.uniprot.org/core/author | "Menzl I."xsd:string |
| http://purl.uniprot.org/citations/20974809 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/20974809 | http://purl.uniprot.org/core/name | "Mol Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/20974809 | http://purl.uniprot.org/core/pages | "215-225"xsd:string |
| http://purl.uniprot.org/citations/20974809 | http://purl.uniprot.org/core/title | "Posttranscriptional suppression of proto-oncogene c-fms expression by vigilin in breast cancer."xsd:string |
| http://purl.uniprot.org/citations/20974809 | http://purl.uniprot.org/core/volume | "31"xsd:string |
| http://purl.uniprot.org/citations/20974809 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20974809 |
| http://purl.uniprot.org/citations/20974809 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20974809 |
| http://purl.uniprot.org/uniprot/#_A0A024R4E5-mappedCitation-20974809 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20974809 |
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| http://purl.uniprot.org/uniprot/#_B4E2Y8-mappedCitation-20974809 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20974809 |
| http://purl.uniprot.org/uniprot/#_Q00341-mappedCitation-20974809 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20974809 |
| http://purl.uniprot.org/uniprot/#_Q2HJC8-mappedCitation-20974809 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20974809 |