| http://purl.uniprot.org/citations/20974939 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20974939 | http://www.w3.org/2000/01/rdf-schema#comment | "Synucleins are a vertebrate-specific family of abundant neuronal proteins. They comprise three closely related members, α-, β-, and γ-synuclein. α-Synuclein has been the focus of intense attention since mutations in it were identified as a cause for familial Parkinson's disease. Despite their disease relevance, the normal physiological function of synucleins has remained elusive. To address this, we generated and characterized αβγ-synuclein knockout mice, which lack all members of this protein family. Deletion of synucleins causes alterations in synaptic structure and transmission, age-dependent neuronal dysfunction, as well as diminished survival. Abrogation of synuclein expression decreased excitatory synapse size by ∼30% both in vivo and in vitro, revealing that synucleins are important determinants of presynaptic terminal size. Young synuclein null mice show improved basic transmission, whereas older mice show a pronounced decrement. The late onset phenotypes in synuclein null mice were not due to a loss of synapses or neurons but rather reflect specific changes in synaptic protein composition and axonal structure. Our results demonstrate that synucleins contribute importantly to the long-term operation of the nervous system and that alterations in their physiological function could contribute to the development of Parkinson's disease."xsd:string |
| http://purl.uniprot.org/citations/20974939 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.1005005107"xsd:string |
| http://purl.uniprot.org/citations/20974939 | http://purl.uniprot.org/core/author | "Williams A.M."xsd:string |
| http://purl.uniprot.org/citations/20974939 | http://purl.uniprot.org/core/author | "Diao L."xsd:string |
| http://purl.uniprot.org/citations/20974939 | http://purl.uniprot.org/core/author | "Tian N."xsd:string |
| http://purl.uniprot.org/citations/20974939 | http://purl.uniprot.org/core/author | "Buchman V.L."xsd:string |
| http://purl.uniprot.org/citations/20974939 | http://purl.uniprot.org/core/author | "Morimoto-Tomita M."xsd:string |
| http://purl.uniprot.org/citations/20974939 | http://purl.uniprot.org/core/author | "Castillo P.E."xsd:string |
| http://purl.uniprot.org/citations/20974939 | http://purl.uniprot.org/core/author | "Chandra S.S."xsd:string |
| http://purl.uniprot.org/citations/20974939 | http://purl.uniprot.org/core/author | "Makani S."xsd:string |
| http://purl.uniprot.org/citations/20974939 | http://purl.uniprot.org/core/author | "Polydoro M."xsd:string |
| http://purl.uniprot.org/citations/20974939 | http://purl.uniprot.org/core/author | "Greten-Harrison B."xsd:string |
| http://purl.uniprot.org/citations/20974939 | http://purl.uniprot.org/core/author | "Nie E.H."xsd:string |
| http://purl.uniprot.org/citations/20974939 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20974939 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/20974939 | http://purl.uniprot.org/core/pages | "19573-19578"xsd:string |
| http://purl.uniprot.org/citations/20974939 | http://purl.uniprot.org/core/title | "alphabetagamma-Synuclein triple knockout mice reveal age-dependent neuronal dysfunction."xsd:string |
| http://purl.uniprot.org/citations/20974939 | http://purl.uniprot.org/core/volume | "107"xsd:string |
| http://purl.uniprot.org/citations/20974939 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20974939 |
| http://purl.uniprot.org/citations/20974939 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20974939 |
| http://purl.uniprot.org/uniprot/Q9Z0F7#attribution-2C18272FBF1359EDF51661DCE5C37164 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/20974939 |
| http://purl.uniprot.org/uniprot/O55042#attribution-2C18272FBF1359EDF51661DCE5C37164 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/20974939 |
| http://purl.uniprot.org/uniprot/Q91ZZ3#attribution-2C18272FBF1359EDF51661DCE5C37164 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/20974939 |
| http://purl.uniprot.org/uniprot/#_O55042-mappedCitation-20974939 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20974939 |