| http://purl.uniprot.org/citations/20974968 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20974968 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20974968 | http://www.w3.org/2000/01/rdf-schema#comment | "The activation and recruitment of the small GTPase Rab7 to early endosome is a critical step for early to late endosome maturation, a process that requires the class III phosphatidylinositol 3-kinase (PI3KC3) and GTPase regulators. However, the molecular mechanism underlying Rab7 activation and endosome maturation is still poorly defined. Here we report that Rubicon, a component of the PI3KC3 complex, prevents endosome maturation through differential interactions with Rab7 and UVRAG. UVRAG activates PI3KC3 and C-VPS/HOPS, a guanine nucleotide exchange factor that catalyzes the exchange of GDP for GTP on Rab7. We demonstrate that Rubicon sequesters UVRAG from C-VPS/HOPS. Active GTP-bound Rab7 competes for Rubicon binding and releases UVRAG to associate with C-VPS/HOPS, which in turn promotes further loading of Rab7 with GTP. This feed-forward loop ensures rapid amplification of GTP-bound Rab7 and consequent stimulation of endosome maturation. Hence, Rubicon serves as a previously unknown Rab7 effector to ensure the proper progression of the endocytic pathway."xsd:string |
| http://purl.uniprot.org/citations/20974968 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.1010554107"xsd:string |
| http://purl.uniprot.org/citations/20974968 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.1010554107"xsd:string |
| http://purl.uniprot.org/citations/20974968 | http://purl.uniprot.org/core/author | "Sun Q."xsd:string |
| http://purl.uniprot.org/citations/20974968 | http://purl.uniprot.org/core/author | "Sun Q."xsd:string |
| http://purl.uniprot.org/citations/20974968 | http://purl.uniprot.org/core/author | "Zhong Q."xsd:string |
| http://purl.uniprot.org/citations/20974968 | http://purl.uniprot.org/core/author | "Zhong Q."xsd:string |
| http://purl.uniprot.org/citations/20974968 | http://purl.uniprot.org/core/author | "Tan I."xsd:string |
| http://purl.uniprot.org/citations/20974968 | http://purl.uniprot.org/core/author | "Tan I."xsd:string |
| http://purl.uniprot.org/citations/20974968 | http://purl.uniprot.org/core/author | "Wong K.N."xsd:string |
| http://purl.uniprot.org/citations/20974968 | http://purl.uniprot.org/core/author | "Wong K.N."xsd:string |
| http://purl.uniprot.org/citations/20974968 | http://purl.uniprot.org/core/author | "Westphal W."xsd:string |
| http://purl.uniprot.org/citations/20974968 | http://purl.uniprot.org/core/author | "Westphal W."xsd:string |
| http://purl.uniprot.org/citations/20974968 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20974968 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20974968 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/20974968 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/20974968 | http://purl.uniprot.org/core/pages | "19338-19343"xsd:string |
| http://purl.uniprot.org/citations/20974968 | http://purl.uniprot.org/core/pages | "19338-19343"xsd:string |
| http://purl.uniprot.org/citations/20974968 | http://purl.uniprot.org/core/title | "Rubicon controls endosome maturation as a Rab7 effector."xsd:string |
| http://purl.uniprot.org/citations/20974968 | http://purl.uniprot.org/core/title | "Rubicon controls endosome maturation as a Rab7 effector."xsd:string |
| http://purl.uniprot.org/citations/20974968 | http://purl.uniprot.org/core/volume | "107"xsd:string |
| http://purl.uniprot.org/citations/20974968 | http://purl.uniprot.org/core/volume | "107"xsd:string |