| http://purl.uniprot.org/citations/20975043 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20975043 | http://www.w3.org/2000/01/rdf-schema#comment | "CD4(+)CD25(+)FoxP3(+) regulatory T cells (T reg cells) play a major role in the control of immune responses but the factors controlling their homeostasis and function remain poorly characterized. Nicotinamide adenine dinucleotide (NAD(+)) released during cell damage or inflammation results in ART2.2-mediated ADP-ribosylation of the cytolytic P2X7 receptor on T cells. We show that T reg cells express the ART2.2 enzyme and high levels of P2X7 and that T reg cells can be depleted by intravenous injection of NAD(+). Moreover, lower T reg cell numbers are found in mice deficient for the NAD-hydrolase CD38 than in wild-type, P2X7-deficient, or ART2-deficient mice, indicating a role for extracellular NAD(+) in T reg cell homeostasis. Even routine cell preparation leads to release of NAD(+) in sufficient quantities to profoundly affect T reg cell viability, phenotype, and function. We demonstrate that T reg cells can be protected from the deleterious effects of NAD(+) by an inhibitory ART2.2-specific single domain antibody. Furthermore, selective depletion of T reg cells by systemic administration of NAD(+) can be used to promote an antitumor response in several mouse tumor models. Collectively, our data demonstrate that NAD(+) influences survival, phenotype, and function of T reg cells and provide proof of principle that acting on the ART2-P2X7 pathway represents a new strategy to manipulate T reg cells in vivo."xsd:string |
| http://purl.uniprot.org/citations/20975043 | http://purl.org/dc/terms/identifier | "doi:10.1084/jem.20091154"xsd:string |
| http://purl.uniprot.org/citations/20975043 | http://purl.uniprot.org/core/author | "Haag F."xsd:string |
| http://purl.uniprot.org/citations/20975043 | http://purl.uniprot.org/core/author | "Koch-Nolte F."xsd:string |
| http://purl.uniprot.org/citations/20975043 | http://purl.uniprot.org/core/author | "Hubert S."xsd:string |
| http://purl.uniprot.org/citations/20975043 | http://purl.uniprot.org/core/author | "Sparwasser T."xsd:string |
| http://purl.uniprot.org/citations/20975043 | http://purl.uniprot.org/core/author | "Seman M."xsd:string |
| http://purl.uniprot.org/citations/20975043 | http://purl.uniprot.org/core/author | "Klages K."xsd:string |
| http://purl.uniprot.org/citations/20975043 | http://purl.uniprot.org/core/author | "Boyer O."xsd:string |
| http://purl.uniprot.org/citations/20975043 | http://purl.uniprot.org/core/author | "Adriouch S."xsd:string |
| http://purl.uniprot.org/citations/20975043 | http://purl.uniprot.org/core/author | "Rissiek B."xsd:string |
| http://purl.uniprot.org/citations/20975043 | http://purl.uniprot.org/core/author | "Huehn J."xsd:string |
| http://purl.uniprot.org/citations/20975043 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20975043 | http://purl.uniprot.org/core/name | "J Exp Med"xsd:string |
| http://purl.uniprot.org/citations/20975043 | http://purl.uniprot.org/core/pages | "2561-2568"xsd:string |
| http://purl.uniprot.org/citations/20975043 | http://purl.uniprot.org/core/title | "Extracellular NAD+ shapes the Foxp3+ regulatory T cell compartment through the ART2-P2X7 pathway."xsd:string |
| http://purl.uniprot.org/citations/20975043 | http://purl.uniprot.org/core/volume | "207"xsd:string |
| http://purl.uniprot.org/citations/20975043 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20975043 |
| http://purl.uniprot.org/citations/20975043 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20975043 |
| http://purl.uniprot.org/uniprot/#_A0A1B0GQV6-mappedCitation-20975043 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20975043 |
| http://purl.uniprot.org/uniprot/#_P56528-mappedCitation-20975043 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20975043 |
| http://purl.uniprot.org/uniprot/#_A2VCP3-mappedCitation-20975043 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20975043 |
| http://purl.uniprot.org/uniprot/#_O35975-mappedCitation-20975043 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20975043 |
| http://purl.uniprot.org/uniprot/#_C8YIX4-mappedCitation-20975043 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20975043 |