| http://purl.uniprot.org/citations/20977916 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20977916 | http://www.w3.org/2000/01/rdf-schema#comment | "Immunoglobulin A deficiency (IgAD) is the most common primary immunodeficiency, with suggested association with various types of autoimmunity, including Graves' disease. This study investigated the association of IgAD with elevated thyrotropin-receptor autoantibodies (TRAb). IgA was measured in TRAb-seropositive individuals from both Iceland (N = 299] and Sweden (N = 841]. In addition, TRAb levels were evaluated in 43 Icelandic and 50 Swedish IgAD individuals using Medizym TRA immunoassay, and positive samples were re-evaluated using BRAHMS TRAK human RIA. The IgAD individuals were HLA-genotyped to determine the HLA-B, DR, and DQ alleles. None of the 299 Icelandic TRAb-seropositive individuals had IgAD, whereas, a high prevalence of IgAD (14/841 (1:60)) was observed in the Swedish cohort (p = 0.027). The prevalence of TRAb-seropositivity in IgAD individuals was, however, increased in both cohorts. The HLA-DQ6 allele was associated with TRAb-seronegativity within the Icelandic IgAD cohort (p = 0.037). The prevalence of IgAD in TRAb-seropositive individuals in Sweden is 10 times higher than expected in the general population. Furthermore, TRAb seropositivity is common among IgAD individuals, both in Iceland and Sweden, suggesting a predisposition toward Graves' disease. These findings underline the significant association of IgAD with autoimmunity and its possible association with certain HLA-DQ alleles."xsd:string |
| http://purl.uniprot.org/citations/20977916 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.humimm.2010.10.014"xsd:string |
| http://purl.uniprot.org/citations/20977916 | http://purl.uniprot.org/core/author | "Wang N."xsd:string |
| http://purl.uniprot.org/citations/20977916 | http://purl.uniprot.org/core/author | "Hammarstrom L."xsd:string |
| http://purl.uniprot.org/citations/20977916 | http://purl.uniprot.org/core/author | "Gudmundsson S."xsd:string |
| http://purl.uniprot.org/citations/20977916 | http://purl.uniprot.org/core/author | "Ludviksson B.R."xsd:string |
| http://purl.uniprot.org/citations/20977916 | http://purl.uniprot.org/core/author | "Janzi M."xsd:string |
| http://purl.uniprot.org/citations/20977916 | http://purl.uniprot.org/core/author | "Johannesson A."xsd:string |
| http://purl.uniprot.org/citations/20977916 | http://purl.uniprot.org/core/author | "Jorgensen G.H."xsd:string |
| http://purl.uniprot.org/citations/20977916 | http://purl.uniprot.org/core/author | "Ornolfsson A.E."xsd:string |
| http://purl.uniprot.org/citations/20977916 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/20977916 | http://purl.uniprot.org/core/name | "Hum Immunol"xsd:string |
| http://purl.uniprot.org/citations/20977916 | http://purl.uniprot.org/core/pages | "166-172"xsd:string |
| http://purl.uniprot.org/citations/20977916 | http://purl.uniprot.org/core/title | "Association of immunoglobulin A deficiency and elevated thyrotropin-receptor autoantibodies in two Nordic countries."xsd:string |
| http://purl.uniprot.org/citations/20977916 | http://purl.uniprot.org/core/volume | "72"xsd:string |
| http://purl.uniprot.org/citations/20977916 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20977916 |
| http://purl.uniprot.org/citations/20977916 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20977916 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C3H3-mappedCitation-20977916 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20977916 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C3I1-mappedCitation-20977916 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20977916 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C3I5-mappedCitation-20977916 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20977916 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C552-mappedCitation-20977916 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20977916 |
| http://purl.uniprot.org/uniprot/#_A0A0E3DC97-mappedCitation-20977916 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20977916 |
| http://purl.uniprot.org/uniprot/#_A0A0E3DC98-mappedCitation-20977916 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20977916 |
| http://purl.uniprot.org/uniprot/#_A0A0E3DC99-mappedCitation-20977916 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20977916 |