| http://purl.uniprot.org/citations/20980265 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20980265 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20980265 | http://www.w3.org/2000/01/rdf-schema#comment | "Iodide (I(-)) is an essential constituent of the thyroid hormones triiodothyronine and thyroxine, which are required for the development of the central nervous system in the fetus and newborn. I(-) uptake in the thyroid is mediated by the Na(+)/I(-) symporter (NIS). NIS has gained particular medical interest due to its sensitivity to the environmental pollutant perchlorate (ClO(4)(-)) and its implication in radioiodide cancer treatment. Recently, others have shown that I(-) absorption in the intestine is mediated by NIS (Nicola, J. P., Basquin, C., Portulano, C., Reyna-Neyra, A., Paroder, M., and Carrasco, N. (2009) Am. J. Physiol. Cell Physiol. 296, C654-662). However, their data suggest the participation of other systems in the homeostasis of I(-), in particular because in vivo uptake studies revealed a ClO(4)(-)-insensitive transport component. Here, we describe Na(+)-coupled I(-) uptake by the human Na(+)/multivitamin transporter (hSMVT), a related protein isolated from the placenta, where it was suggested to supply the fetus with the water-soluble vitamins biotin and pantothenic acid, and α-lipoic acid. hSMVT-mediated Na(+)/I(-) symport is inhibited by the other three organic hSMVT substrates but not by NIS substrates; notably, hSMVT is insensitive to ClO(4)(-). Because hSMVT is found in the intestine and in many other tissues, we propose that hSMVT may play an important role in the homeostasis of I(-) in the body."xsd:string |
| http://purl.uniprot.org/citations/20980265 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m110.167197"xsd:string |
| http://purl.uniprot.org/citations/20980265 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m110.167197"xsd:string |
| http://purl.uniprot.org/citations/20980265 | http://purl.uniprot.org/core/author | "Quick M."xsd:string |
| http://purl.uniprot.org/citations/20980265 | http://purl.uniprot.org/core/author | "Quick M."xsd:string |
| http://purl.uniprot.org/citations/20980265 | http://purl.uniprot.org/core/author | "de Carvalho F.D."xsd:string |
| http://purl.uniprot.org/citations/20980265 | http://purl.uniprot.org/core/author | "de Carvalho F.D."xsd:string |
| http://purl.uniprot.org/citations/20980265 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/20980265 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/20980265 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/20980265 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/20980265 | http://purl.uniprot.org/core/pages | "131-137"xsd:string |
| http://purl.uniprot.org/citations/20980265 | http://purl.uniprot.org/core/pages | "131-137"xsd:string |
| http://purl.uniprot.org/citations/20980265 | http://purl.uniprot.org/core/title | "Surprising substrate versatility in SLC5A6: Na+-coupled I- transport by the human Na+/multivitamin transporter (hSMVT)."xsd:string |
| http://purl.uniprot.org/citations/20980265 | http://purl.uniprot.org/core/title | "Surprising substrate versatility in SLC5A6: Na+-coupled I- transport by the human Na+/multivitamin transporter (hSMVT)."xsd:string |
| http://purl.uniprot.org/citations/20980265 | http://purl.uniprot.org/core/volume | "286"xsd:string |
| http://purl.uniprot.org/citations/20980265 | http://purl.uniprot.org/core/volume | "286"xsd:string |
| http://purl.uniprot.org/citations/20980265 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20980265 |
| http://purl.uniprot.org/citations/20980265 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20980265 |
| http://purl.uniprot.org/citations/20980265 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20980265 |
| http://purl.uniprot.org/citations/20980265 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20980265 |
| http://purl.uniprot.org/uniprot/Q9Y289 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/20980265 |
| http://purl.uniprot.org/uniprot/Q9Y289#attribution-16FA04B2D4F3D1AAF2F11BE1CEC06AF8 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/20980265 |